A review of the recent advances in antimicrobial coatings for urinary catheters.
A review of the recent advances in antimicrobial coatings for urinary catheters.
复制标题
DOI：
10.1016/j.actbio.2016.11.070
复制
发表时间：
2017-03-01
影响因子：
9.7
通讯作者：
Handa H
中科院分区：
文献类型：
--
作者：
Singha P;Locklin J;Handa H
超过75%的医院获得性或医院内尿路感染是由导尿管引起的，导尿管在15-25%的住院患者的治疗过程中使用。除其他目的外，导尿管主要用于手术后引流尿液和尿失禁。在导尿管相关的尿路感染中，细菌向上移动到膀胱并引起感染。导尿管相关性尿路感染的一个主要原因是在导尿管的制造中使用了非理想的材料。这些材料允许微生物定植，导致菌尿和感染，这取决于症状的严重程度。理想的导尿管由生物相容性、抗菌性和可降解性的材料制成。尽管在过去的45年里，人们对这一主题进行了大量的研究，但理想的生物材料，特别是用于超过一个月的长期导管插入术的生物材料，尚未开发出来。本文综述了近10年来导尿管抗菌材料的研究进展，并对导尿管材料的选择和设计提出了新的要求。
More than 75% of hospital-acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 15–25% of hospitalized patients. Among other purposes, urinary catheters are primarily used for draining urine after surgeries and for urinary incontinence. During catheter-associated urinary tract infections, bacteria travel up to the bladder and cause infection. A major cause of catheter-associated urinary tract infection is attributed to the use of non-ideal materials in the fabrication of urinary catheters. Such materials allow for the colonization of microorganisms, leading to bacteriuria and infection, depending on the severity of symptoms. The ideal urinary catheter is made out of materials that are biocompatible, antimicrobial, and antifouling. Although an abundance of research has been conducted over the last forty-five years on the subject, the ideal biomaterial, especially for long-term catheterization of more than a month, has yet to be developed. The aim of this review is to highlight the recent advances (over the past 10 years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.