Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study
Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study
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DOI：
10.1080/10934529.2015.1087753
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发表时间：
2016-01-28
影响因子：
2.1
通讯作者：
Van de Bor, Margot
中科院分区：
文献类型：
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作者：
de Cock, Marijke;De Boer, Michiel R.;Van de Bor, Margot
产前接触干扰内分泌的化学物质可能会通过扰乱激素的作用和表观遗传修饰影响胎儿发育，潜在地使个体日后易患肥胖症等健康风险。本研究的目的是在荷兰新建立的前瞻性母婴队列中确定各种内分泌干扰化学物质的生物暴露标志物与出生体重之间的关系。从出生记录中获得出生体重（n = 91），并测定脐带血浆中暴露于二氯二苯二氯乙烯（DDE）、三种邻苯二甲酸二-2-乙基己基酯（DEHP）代谢物、多氯联苯-153、全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的情况。对于DDE，也测量了母乳中的暴露量。使用线性回归分析来确定化合物与出生体重之间的关系，并根据性别对其进行分层，并根据先验定义的协变量进行调整。DDE暴露增加与男孩较低的出生体重相关（>95.89 ng L-1, -325.9 g, 95% CI -634.26至-17.56），而在女孩中观察到较高的出生体重趋势。高暴露于MECPP的男孩出生体重较低，在一定程度上暴露于PFOA的男孩出生体重较低。另一方面，接触MEHHP和全氟辛烷磺酸与男孩出生体重较高有关。在女孩中没有观察到这些化合物的作用。可以得出结论，产前暴露于DDE、全氟烷基酸和邻苯二甲酸酯与该人群出生体重的变化有关。这种关联与性别有关，似乎是非线性的。由于研究对象相对较少，对结果的解释应谨慎。
Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L-1, -325.9 g, 95% CI -634.26 to -17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution.