Inhibition of carcinogenesis by retinoids.
Inhibition of carcinogenesis by retinoids.
复制标题
类维生素A抑制致癌作用。
作者：
R. Moon;D. Mccormick;R. Mehta
类维生素A是实验动物乳腺和膀胱化学致癌作用的有效抑制剂。类维生素A基本结构的修饰产生了具有增加的靶器官特异性的类维生素A，导致抗癌活性增加，全身毒性降低。将类维生素A治疗与激素操作相结合，可协同抑制乳腺癌的发生;这种联合方法还可抑制首次乳腺癌手术切除后发生其他乳腺癌。类维生素A在致癌损伤后不久给药时最有效。然而，即使当类维生素A治疗延迟时，该化合物仍然是乳腺和膀胱的有效癌症化学预防剂。类维生素A暴露可以延迟并保持抗癌作用的时间长度与肿瘤潜伏期直接相关，对于具有长潜伏期的肿瘤允许更长的延迟。
Retinoids are effective inhibitors of chemical carcinogenesis in the mammary gland and urinary bladder of experimental animals. Modification of the basic retinoid structure has produced retinoids with increased target organ specificity, resulting in increased anticancer activity with reduced systemic toxicity. Combining retinoid treatment with hormonal manipulation results in a synergistic inhibition of mammary carcinogenesis; this combination approach also inhibits development of additional mammary cancers following surgical removal of the first mammary cancer. Retinoids are most effective when administered shortly after the carcinogenic insult. However, even when retinoid treatment is delayed, the compounds are still effective cancer chemopreventive agents for the mammary gland and urinary bladder. The length of time that retinoid exposure can be delayed and retain an anticancer effect is directly related to tumor latency, with a longer delay permissible against tumors with long latent periods.