Ovarian fibroma/fibrothecoma with elevated serum CA125 level A cohort of 66 cases
Ovarian fibroma/fibrothecoma with elevated serum CA125 level A cohort of 66 cases
复制标题
DOI：
10.1097/md.0000000000011926
复制
发表时间：
2018-08-01
期刊：
影响因子：
1.6
通讯作者：
Wan, Xiaoyun
中科院分区：
文献类型：
--
作者：
Shen, Yuanming;Liang, Yun;Wan, Xiaoyun
卵巢纤维瘤/卵泡膜细胞瘤血清OC 125抗原（CA 125）升高在临床上很少见，也容易误诊为上皮性卵巢癌（EOC）。为探讨血清CA 125升高的卵巢纤维瘤/卵泡膜纤维瘤的临床病理特征，对580例经手术病理证实的卵巢纤维瘤/卵泡膜纤维瘤患者进行回顾性分析。比较血清CA 125升高（>35 U/mL）与无血清CA 125升高患者的临床病理参数。采用免疫组化法检测卵巢纤维瘤/卵泡膜纤维瘤及上皮性癌组织中CA 125的表达情况。单因素和多因素分析，以确定与血清CA 125水平升高的相关因素。580例卵巢纤维瘤/卵泡膜纤维瘤中66例（11.3%）血清CA_（125）水平升高（36.7 ~ 1848 u/m ~ 2）。单因素分析显示肿瘤直径≥ 10 cm与血清CA 125水平显著相关（P
Ovarian fibroma/fibrothecoma with elevated serum OC125 antigen (CA125) is rarely encountered in clinical practice, and also easily misdiagnosed as epithelial ovarian carcinoma (EOC). The aim of this study was to investigate the clinicopathological features of ovarian fibroma/fibrothecoma with elevated serum CA125.In total, 580 patients who underwent primary surgery and pathologically diagnosed as ovarian fibroma/fibrothecoma were retrospectively analyzed. The clinicopathological parameters were collected and compared between the patients with elevated serum CA125(>35 U/mL) and without. The immunoreactivity for CA125 in ovarian fibroma/fibrothecoma and epithelial cancer tissues was detected and compared by immunohistochemistry. Univariate and multivariate analyses were performed to identify factors associated with elevated serum CA125 level. The correlation between the immunoreactivity of CA125 in tissue and serum CA125 level was examined by Pearson correlation analysis.Elevated serum CA125 level (range 36.7-1848u/m) was found in 66 of 580 (11.3%) ovarian fibroma/fibrothecoma patients. Univariate analysis showed that the elevated serum CA125 level was significantly correlated with tumor diameter >= 10cm (P