Selective Alkylation of (Hetero)Aromatic Amines with Alcohols Catalyzed by a Ruthenium Pincer Complex
Selective Alkylation of (Hetero)Aromatic Amines with Alcohols Catalyzed by a Ruthenium Pincer Complex
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DOI：
10.1021/ol3001969
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发表时间：
2012-03-16
期刊：
影响因子：
5.2
通讯作者：
Martin-Matute, Belen
中科院分区：
文献类型：
--
作者：
Agrawal, Santosh;Lenormand, Maud;Martin-Matute, Belen
一种易于获得的钳形钌（II）配合物催化（杂）芳胺与多种伯醇（包括吡啶-，呋喃-和噻吩取代醇）的选择性单烷基化，在低催化剂负载（1摩尔%）下使用时效率很高。通过多烷基化不会产生叔胺，使该钌体系成为合成仲胺的极好催化剂。
A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst for the synthesis of sec-amines.