Macro FTIR imaging in transmission under a controlled environment
Macro FTIR imaging in transmission under a controlled environment
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DOI：
10.1016/j.vibspec.2005.10.005
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发表时间：
2006-10-18
影响因子：
2.5
通讯作者：
Kazarian, S. G.
中科院分区：
文献类型：
--
作者：
Chan, K. L. A.;Kazarian, S. G.
通过使用专门制造的附件，展示了宏观FTIR成像的新发展。该附件扩展了宏观FTIR成像在受控环境下样品研究中的可能应用。这一新的附件使样品(如胶片)能够在水平位置进行测量，并在传输过程中进行宏观FTIR成像。这增加了样品布置的灵活性，并提供了使用受控环境池进行宏观FTIR成像的机会。采用这种方法，在受控湿度和温度的环境下，用FTIR成像技术在3.8 mm×3.8 mm的面积上监测了非晶态硝苯地平薄膜的结晶和多晶性变化。展示的成像方法可能会影响到聚合物和生物医学材料、制药和高通量分析等多个领域。(C)2005 Elsevier B.V.保留所有权利。
New development in macro FTIR imaging with the use of a specially built accessory has been demonstrated. This accessory expands the possible applications of using macro FTIR imaging in the study of samples under a controlled environment. This new accessory enables the samples (such as films) to be measured in the horizontal position with macro FTIR imaging in transmission. This adds to the flexibility of the sample arrangement and provides the opportunity to use the controlled environment cell for macro FTIR imaging. Using this approach, the crystallisation and the polymorphic changes of amorphous nifedipine film has been monitored by using FTIR imaging over an area of 3.8 mm x 3.8 mm under a controlled humidity and temperature environment. The demonstrated imaging approach may impact areas as diverse as polymeric and biomedical materials, pharmaceuticals and high-throughput analysis. (C) 2005 Elsevier B.V. All rights reserved.