CORTICOTROPIN-RELEASING HORMONE IS A RAPID AND POTENT CONVULSANT IN THE INFANT RAT
CORTICOTROPIN-RELEASING HORMONE IS A RAPID AND POTENT CONVULSANT IN THE INFANT RAT
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DOI：
10.1016/0165-3806(91)90118-3
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发表时间：
1991-07-16
期刊：
影响因子：
--
通讯作者：
SCHULTZ, L
中科院分区：
文献类型：
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作者：
BARAM, TZ;SCHULTZ, L
促肾上腺皮质激素释放激素（CRH）给药到脑室的大鼠在出生后的第一周引起了一个特定的和刻板的行为序列：有节奏的咀嚼和舔（颌肌阵挛），其次是“边缘”型癫痫发作。与成年大鼠相比，癫痫发作更快（2-45分钟vs 3-7小时），惊厥剂量也更低（50 x 10（-12）mol/g脑重vs 750 x 10（-12）mol/g脑重）。CRH诱导癫痫发作的效力与年龄成反比。CRH诱导的癫痫发作发生在血清皮质酮的任何变化之前，并通过CRH拮抗剂和苯妥英的给药消除。皮层脑电图相关的CRH诱导的行为在幼年大鼠是不一致的，这表明在未成熟的大脑CRH诱导的突发性事件的皮质下起源。
Corticotropin-releasing hormone (CRH) administered into the cerebral ventricles of rats during the first postnatal week caused a specific and stereotyped behavior sequence: rhythmic chewing and licking (jaw myoclonus) were followed by 'limbic'-type seizures. The onset of the seizures was much more rapid (2-45 min vs 3-7 h) than in adult rats, and the convulsant doses were much lower (50 x 10(-12) mol per gram brain weight vs 750 x 10(-12) mol per gram brain weight in adults). CRH potency in inducing seizures varied inversely with age. CRH-induced seizures occurred prior to any changes in serum corticosterone, and were eliminated by the administration of a CRH antagonist, as well as of phenytoin. Electrocorticographic correlates of CRH-induced behaviors in the infant rat were inconsistent, suggesting a subcortical origin of CRH-induced paroxysmal events in the immature brain.