Beyond extinction: erasing human fear responses and preventing the return of fear
Beyond extinction: erasing human fear responses and preventing the return of fear
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DOI：
10.1038/nn.2271
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发表时间：
2009-03-01
影响因子：
25
通讯作者：
Vervliet, Bram
中科院分区：
文献类型：
--
作者：
Kindt, Merel;Soeter, Marieke;Vervliet, Bram
动物研究表明，恐惧记忆在回忆时会发生变化，这一过程被称为重新巩固。我们发现，口服β-肾上腺素能受体拮抗剂普萘洛尔在人类记忆再激活前消除了恐惧记忆的行为表达24小时后，并防止恐惧的回归。破坏恐惧记忆的重新巩固为情绪障碍患者提供长期治疗开辟了新的途径。
Animal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later and prevented the return of fear. Disrupting the reconsolidation of fear memory opens up new avenues for providing a long-term cure for patients with emotional disorders.