Follow-up study of a patient with early onset cerebral amyloid angiopathy following childhood cadaveric dural graft
Follow-up study of a patient with early onset cerebral amyloid angiopathy following childhood cadaveric dural graft
复制标题
儿童尸体硬脑膜移植后早发脑淀粉样血管病患者的随访研究
作者：
Kenji Yoshiki;G. Hirose;Kazuhiko Kumahashi;Y. Kohda;K. Ido;A. Shioya;K. Misaki;K. Kasuga
我们回顾性研究了一名40岁的患者的T2星星（T2*）加权磁共振成像（MRI），该患者被诊断为症状性早发性脑淀粉样血管病（CAA），发生在儿童神经外科手术后34年，使用尸体硬脑膜补片。我们的研究结果显示，与尸体硬脑膜移植相关的CAA进展迅速，有时伴有双侧出血。这种微出血演变表明，由于清除障碍，水溶性淀粉样蛋白-β通过脑脊液沿血管周围引流途径传播，并沉积在脑动脉壁中。与CAA相关的多发性脑内血肿伴儿童尸体硬脑膜移植应被视为危及生命的医疗并发症。
We retrospectively studied the T2 star (T2*)-weighted magnetic resonance imaging (MRI) of a 40-year-old patient diagnosed with symptomatic early-onset cerebral amyloid angiopathy (CAA), occurring 34 years following childhood neurosurgery using a cadaveric dural patch. Our findings revealed that CAA associated with cadaveric dural transplantation could progress rapidly, sometimes with bilateral bleeding. This microbleed evolution is suggestive of water-soluble amyloid-β transmission via cerebrospinal fluid alongside perivascular drainage pathways with deposition in the cerebral artery walls due to clearance disturbances. Multiple intracerebral hemorrhages associated with CAA with a childhood cadaveric dural graft should be considered a life-threatening medical complication.
影响因子：
8.3
作者：
Greenberg SM;Charidimou A
通讯作者：
Charidimou A