Haploid selection within a single ejaculate increases offspring fitness
Haploid selection within a single ejaculate increases offspring fitness
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DOI：
10.1073/pnas.1705601114
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发表时间：
2017-07-25
影响因子：
11.1
通讯作者：
Immler, Simone
中科院分区：
文献类型：
--
作者：
Alavioon, Ghazal;Hotzy, Cosima;Immler, Simone
真核生物有性生殖的一个不可避免的结果是进化出一个双相生命周期，二倍体和单倍体阶段交替出现。在单倍体阶段发生的选择可以对基本的进化过程产生深远的影响，包括适应率，近交衰退的程度和有害突变的负荷，以及对受精技术的应用研究。虽然植物中的单倍体选择已经建立，但目前的理论认为，在动物中，一次射精中完整的可育精子在产生可育后代方面是等同的。使用斑马鱼，我们表明，选择完整的受精精子之间的射精影响后代的健身表型变异。寿命较长的精子繁殖的胚胎存活率增加，凋亡细胞数量减少，成年雄性后代表现出更高的适应性。对胚胎存活力的影响在没有进一步选择的情况下延续到第二代，并且在两种性别中同样强烈。通过运动表型选择的精子池在整个基因组的许多位点上存在遗传差异。我们的研究结果清楚地连接精子表型的后代健身和精子基因型在脊椎动物的射精内的变化，并有重大意义的适应性进化。
An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring. Using the zebrafish Danio rerio, we show that selection on phenotypic variation among intact fertile sperm within an ejaculate affects offspring fitness. Longer-lived sperm sired embryos with increased survival and a reduced number of apoptotic cells, and adult male offspring exhibited higher fitness. The effect on embryo viability was carried over into the second generation without further selection and was equally strong in both sexes. Sperm pools selected by motile phenotypes differed genetically at numerous sites throughout the genome. Our findings clearly link within-ejaculate variation in sperm phenotype to offspring fitness and sperm genotype in a vertebrate and have major implications for adaptive evolution.