Design of a breast phantom for quantitative MRI
Design of a breast phantom for quantitative MRI
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DOI：
10.1002/jmri.25214
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发表时间：
2016-09-01
影响因子：
4.4
通讯作者：
Hylton, Nola M.
中科院分区：
文献类型：
--
作者：
Keenan, Kathryn E.;Wilmes, Lisa J.;Hylton, Nola M.
目的我们提出了一种乳房体模，旨在对 T-1 弛豫时间、表观扩散系数 (ADC) 和乳房组织的其他属性的测量进行定量评估，并得到国家计量研究所的长期支持。材料和方法乳房体模由两个独立的、可互换的扩散和 T-1/T-2 松弛单元创建，每个单元都有柔性外壳。 T-1 装置充满玉米糖浆溶液和葡萄籽油，分别模拟纤维腺体和脂肪组织的松弛行为。扩散单元包含充满聚乙烯吡咯烷酮 (PVP) 水溶液的塑料管，用于调节 ADC。使用磁共振成像 (MRI) 扫描仪和来自多个制造商的常见乳腺线圈对体模进行 1.5T 和 3.0T 成像，以评估 T-1 和 T-2 弛豫时间和 ADC 值。结果纤维腺模拟物在 1.5T 和 3.0T 临床系统上表现出目标 T-1 值（25-75 百分位范围：1289 至 1400 毫秒和 1533 至 1845）毫秒）在所有孔温度范围内。 PVP 解决方案模拟了 17-24 摄氏度下从恶性肿瘤到正常乳腺组织的 ADC 值范围（40% PVP 中位数：633 x 10(-6) mm(2)/s 到 0% PVP 中位数：2231 x 10(-6) mm(2)/s）。可互换的模型单元允许在线圈的左侧和右侧测试扩散和 T-1/T-2 单元，以确保结论该体模能够进行 T-1 和 ADC 测量，适合各种临床乳腺线圈，并且可以作为质量控制工具，促进乳腺 MRI 定量测量的标准化。 J.马格。共振。成像 2016 年；44：610-619。
PurposeWe present a breast phantom designed to enable quantitative assessment of measurements of T-1 relaxation time, apparent diffusion coefficient (ADC), and other attributes of breast tissue, with long-term support from a national metrology institute.Materials and MethodsA breast phantom was created with two independent, interchangeable units for diffusion and T-1/T-2 relaxation, each with flexible outer shells. The T-1 unit was filled with corn syrup solution and grapeseed oil to mimic the relaxation behavior of fibroglandular and fatty tissues, respectively. The diffusion unit contains plastic tubes filled with aqueous solutions of polyvinylpyrrolidone (PVP) to modulate the ADC. The phantom was imaged at 1.5T and 3.0T using magnetic resonance imaging (MRI) scanners and common breast coils from multiple manufacturers to assess T-1 and T-2 relaxation time and ADC values.ResultsThe fibroglandular mimic exhibited target T-1 values on 1.5T and 3.0T clinical systems (25-75 percentile range: 1289 to 1400 msec and 1533 to 1845 msec, respectively) across all bore temperatures. PVP solutions mimicked the range of ADC values from malignant tumors to normal breast tissue (40% PVP median: 633 x 10(-6) mm(2)/s to 0% PVP median: 2231 x 10(-6) mm(2)/s) at temperatures of 17-24 degrees C. The interchangeable phantom units allowed both the diffusion and T-1/T-2 units to be tested on the left and right sides of the coil to assess any variation.ConclusionThis phantom enables T-1 and ADC measurements, fits in a variety of clinical breast coils, and can serve as a quality control tool to facilitate the standardization of quantitative measurements for breast MRI. J. Magn. Reson. Imaging 2016;44:610-619.