Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion.
Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion.
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DOI：
10.1056/nejm200112133452412
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发表时间：
2001-12-13
影响因子：
158.5
通讯作者：
Langin, D
中科院分区：
文献类型：
--
作者：
Langin, D
分泌胰岛素的胰岛细胞的胞浆是一个生化蜂巢，其中葡萄糖氧化产物影响胰岛素的分泌。对培养的胰岛的研究表明，称为解偶联蛋白2（UCP 2）的线粒体离子载体影响葡萄糖刺激的胰岛素水平。最近的一份报告表明，在UCP-2基因缺失的小鼠中，胰岛素分泌增强，血糖水平降低。当该基因被敲除时，肥胖、胰岛素抵抗和糖尿病的inob/ob小鼠的胰岛素分泌增加，高血糖得到改善。
The mitochondrion of the insulin-secreting pancreatic islet cell is a biochemical beehive in which the products of glucose oxidation influence the secretion of insulin. Work with cultured islets has shown that a mitochondrial ion carrier termed uncoupling protein 2 (UCP2) affects glucose-stimulated insulin levels. A recent report demonstrated that in mice with a disabledUCP-2gene, insulin secretion was enhanced and blood levels of glucose were reduced. When the gene was knocked out inob/obmice, which are obese, insulin-resistant, and diabetic, insulin secretion increased and the hyperglycemia was ameliorated.