Maternal serum and cord blood preptin levels in gestational diabetes mellitus
Maternal serum and cord blood preptin levels in gestational diabetes mellitus
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DOI：
10.1038/jp.2010.125
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发表时间：
2011-05-01
影响因子：
2.9
通讯作者：
Kafkasli, A.
中科院分区：
文献类型：
--
作者：
Aslan, M.;Celik, O.;Kafkasli, A.
目的：为了评估preptin浓度在孕妇和没有妊娠糖尿病（GDM）和脐带血中的胎儿。研究设计：在所有，31名孕妇与GDM和31胎龄匹配的健康孕妇参加。用ELISA法检测孕妇血清和脐带血preptin水平。结果：GDM组孕妇血清及脐血Preptin水平均高于对照组，GDM组孕妇血清及脐血Preptin水平均高于对照组，GDM组孕妇血清及脐血Preptin水平均高于对照组。孕妇血清Preptin浓度与孕妇年龄、空腹胰岛素水平、糖负荷后1 h血糖和出生时脐带Preptin浓度呈正相关。然而，母亲和/或脐带血清preptin和胎儿的生长参数之间的关系在birth.Conclusion：我们的研究结果表明，preptin浓度增加，孕妇血清中的GDM的妇女。Preptin水平可能提供一种新的方法来识别女性GDM。Journal of Perinatology（2011）31，350-355; doi：10.1038/jp.2010.125; 2010年12月16日在线发表
Objective: To assess preptin concentrations in pregnant women with and without gestational diabetes mellitus (GDM) and in the cord blood of their fetuses.Study Design: In all, 31 pregnant women with GDM and 31 gestational age-matched healthy pregnant subjects participated. Maternal serum and cord blood preptin levels were measured with ELISA. The relationships between maternal serum and cord blood preptin levels, anthropometric and metabolic parameters were also assessed.Result: Maternal serum and cord blood preptin levels were found higher in patients with GDM compared with control pregnant women. Preptin concentration in maternal serum was positively correlated with maternal age, fasting insulin levels, 1-h blood glucose after glucose load and cord preptin concentrations at birth. However, relationships between maternal and/or cord serum preptin and fetal growth parameters at birth were not detected.Conclusion: Our results indicate that preptin concentrations increase in maternal serum of women with GDM. Preptin levels may provide a novel approach to identify women with GDM. Journal of Perinatology (2011) 31, 350-355; doi:10.1038/jp.2010.125; published online 16 December 2010