The histological structure of some human lung cancers and the possible implications for radiotherapy.
The histological structure of some human lung cancers and the possible implications for radiotherapy.
复制标题
某些人类肺癌的组织学结构以及对放射疗法的可能影响。
DOI：
10.1038/bjc.1955.55
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发表时间：
1955-12
影响因子：
8.8
通讯作者：
GRAY, L H
中科院分区：
文献类型：
--
作者：
THOMLINSON, R H;GRAY, L H
复层鳞状上皮的细胞，无论是正常的还是肿瘤的，通常保持彼此接触。它们的营养所依赖的血管基质与上皮接触，但毛细血管不穿透各个细胞之间。由这些细胞组成的肿瘤通常以实心棒状生长，当在与其轴成直角的平面中切割的组织学切片中观察时，这些肿瘤表现为被基质包围的圆形区域。在这种肿瘤中，较大区域的中心是坏死的，并被呈环状的完整肿瘤细胞包围。似乎这种特殊结构可能对此类肿瘤的放射治疗具有重要影响，因为每个肿瘤索的外围和中心之间必然存在氧张力下降梯度，并且众所周知，在辐射时缺氧的细胞通常受到给定剂量的缺氧的损害要小得多。 X 或 y 辐射高于那些氧合良好的辐射（Gray 等人，1953）。
THE cells of stratified squamous epithelium, whether normal or neoplastic, generally remain in contact with one another. The vascular stroma on which their nutrition depends lies in contact with the epithelium but the capillaries do not penetrate between the individual cells. Tumours composed of these cellsoften grow in solid rods which, whenseen in histological sections cut in a plane at right angles to their axes, appear as circular areas surrounded by stroma. In tumours of this kind the centres of the larger areas are necrotic and are surrounded by intact tumour cells which appear as rings.It appeared that this particular structure might have an important bearing on the radiotherapy of such tumours, since there must exist a falling gradient in oxygen tension between the periphery and the centre of each tumour cord, and it is well known that cells which are anoxic at the time of irradition are generally much less damaged by a given dose of X-or y-radiation than those which are well oxygenated (Gray et al., 1953).