Higher level of circulating estradiol is associated with lower frequency of cognitive impairment in Southeast China
Higher level of circulating estradiol is associated with lower frequency of cognitive impairment in Southeast China
复制标题
中国东南部地区循环雌二醇水平较高与认知障碍发生率较低相关
DOI：
10.1080/09513590.2017.1320379
复制
发表时间：
2017-01-01
影响因子：
2
通讯作者：
Zhou, Jianhong
中科院分区：
文献类型：
--
作者：
Hu, Jiling;Chu, Ketan;Zhou, Jianhong
摘要背景：雌激素已被证明对大脑认知功能具有积极作用。然而，许多调查围绝经期和绝经后妇女认知功能与循环雌激素水平之间关系的临床研究显示了有争议的结果。方法：获取 199 名围绝经期和绝经后女性（平均年龄：49.61 岁）的循环雌二醇和卵泡刺激素 (FSH) 水平。认知功能使用北京版蒙特利尔认知评估进行评估。结果：结果显示，在围绝经期和绝经后女性中，较高的雌二醇水平与更好的认知功能相关（p<<0.05），而 FSH 水平与认知表现无关。结论：在围绝经期和绝经后女性中，循环雌二醇水平较高与认知障碍风险较低相关。
Abstract Background: Estrogen has been proved to have positive effects on the brain cognitive function. However, many clinical studies investigating the associations between cognitive functions and circulating estrogen levels in perimenopausal and postmenopausal women demonstrated controversial results. Method: Circulating estradiol and follicle stimulating hormone (FSH) levels were obtained from 199 perimenopausal and postmenopausal women (mean age: 49.61 years). The cognitive function has been assessed using the Beijing version of the Montreal Cognitive Assessment. Results: Results revealed that higher estradiol levels were associated with better cognitive function (p < 0.05) both in perimenopausal and postmenopausal women and levels of FSH were unrelated to cognitive performance. Conclusions: In perimenopausal and postmenopausal women, higher levels of circulating estradiol are associated with lower risk of cognitive impairment.