Rheological studies of hyaluronan solutions based on the scaling law and constitutive models
Rheological studies of hyaluronan solutions based on the scaling law and constitutive models
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DOI：
10.1016/j.polymer.2013.11.047
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发表时间：
2014-01
期刊：
影响因子：
4.6
通讯作者：
Fengyuan Yu;Fei Zhang;T. Luan;Zinan Zhang;Hongbin Zhang
中科院分区：
文献类型：
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作者：
Fengyuan Yu;Fei Zhang;T. Luan;Zinan Zhang;Hongbin Zhang
研究了透明质酸(HA)无盐和盐水溶液的流变行为与浓度的标度关系，采用三种粘弹性本构模型预测了不同相对分子质量的HA水溶液在20 mg/ml以下的线性/非线性粘弹性行为，得到了一系列浓度方程来描述HA浓度对溶液粘度的影响。与稀释和半稀浓度区相对应，无盐HA溶液的比粘度与HA浓度的标度关系分别为ηsp∼c1.0和ηsp∼c3.5，而对于0.15M的NaClHA溶液，其标度指数分别为1.5和4.2。模拟结果表明，这些本构模型对于定量描述HA缠绕溶液在动态和稳态剪切流动下的流变性具有良好的适用性。此外，HA溶液的平台模数标度可以用浓度相关的长度标度来很好地描述。
We have investigated the scaling relationship between rheological behavior and concentration for both salt-free and saline solutions of hyaluronan (HA), and adopted three viscoelastic constitutive models to predict the linear/non-linear viscoelastic behavior of these aqueous solutions of HA with different molecular weights at different concentrations up to 20 mg/ml. A series of concentration equations are obtained to describe the influence of HA concentration on solution viscosity. Corresponding to dilute and semi-dilute concentration region, salt-free HA solutions have scaling relationship between specific viscosity and HA concentration asηsp∼c1.0andηsp∼c3.5, respectively, while for 0.15 M NaCl HA solutions, the scaling exponents are 1.5 and 4.2, respectively. Simulation results indicate that these constitutive models have good applicability to describe quantitatively the rheological properties of HA entangled solutions under either dynamic or steady shear flow. In addition, the plateau modulus scaling of HA solutions can be well described by the concentration-dependent length scale.