Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma
Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma
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DOI：
10.1016/j.humpath.2010.01.005
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发表时间：
2010-07-01
期刊：
影响因子：
3.3
通讯作者：
Chang, Kai-Ping
中科院分区：
文献类型：
--
作者：
Hsueh, Chuen;Chang, Yu-Sun;Chang, Kai-Ping
紧密连接蛋白是调节紧密连接的完整性和功能的主要紧密连接蛋白。claudins的异常表达已被证明在各种癌症与不同的预后影响。然而，它们在鼻咽癌中的表达模式和预后价值尚未研究。这是第一项研究，以表征表达模式的claudins I，4和7在一个队列的176例鼻咽癌患者和最低随访9.4年。对176例活检标本进行免疫组织化学半定量评估，评估claudins 1、4和7的表达。结果与性别、年龄、肿瘤范围、淋巴结状态、有无远处转移和患者生存相关。claudin 1和claudin 4高表达（72.2%和88.1%），claudin 7低表达（82.4%）。claudin 4低表达（P = 0.020）和claudin 7高表达（P <0.001）与远处转移相关。claudin 7表达升高也与高肿瘤分期相关（P = 0.001）。此外，通过考克斯回归分析，claudin 4表达降低（P = .003）和claudin 7表达增加（P < .001）独立预测较短的无远处转移生存期。Claudin 4和claudin 7可能是预测鼻咽癌远处转移和预后不良的新的生物标志物。(C)2010年爱思唯尔公司All rights reserved.
Claudins are major tight junction proteins that regulate the integrity and function of tight junctions. Aberrant expression of claudins has been shown in various carcinomas with diverse prognostic implications. However, their expression pattern and prognostic value have not been investigated in nasopharyngeal carcinoma. This is the first study to characterize the expression pattern of claudins I, 4, and 7 in a cohort of 176 patients with nasopharyngeal carcinoma and a minimum follow-up of 9.4 years. Immunohistochemistry with semiquantitative assessment of expression of claudins 1, 4, and 7 was performed on 176 biopsy specimens. Results were correlated with sex, age, extent of tumor, lymph node status, the presence or absence of distant metastasis, and patient survival. High expression of claudins 1 and 4 (72.2% and 88.1%) and low expression of claudin 7 (82.4%) were frequently detected. Low claudin 4 expression (P = .020) and high claudin 7 expression (P < .001) were associated with distant metastasis. Elevated claudin 7 expression also correlated with high tumor stage (P = .001). Furthermore, decreased claudin 4 expression (P = .003) and increased claudin 7 expression (P < .001) independently predicted shorter distant metastasis-free survival by Cox regression analysis. Claudin 4 and claudin 7 may be a novel biomarker for the prediction of distant metastasis and unfavorable prognosis in nasopharyngeal carcinoma. (C) 2010 Elsevier Inc. All rights reserved.