Effect of acute kidney injury on long-term outcomes of spontaneous bacterial peritonitis in cirrhotic patients using the International Club of Ascites-acute kidney injury criteria
Effect of acute kidney injury on long-term outcomes of spontaneous bacterial peritonitis in cirrhotic patients using the International Club of Ascites-acute kidney injury criteria
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DOI：
10.1111/jgh.14871
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发表时间：
2019-12-09
影响因子：
4.1
通讯作者：
Cho, Ju-Yeon
中科院分区：
文献类型：
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作者：
Sohn, Won;Kim, Jung Hee;Cho, Ju-Yeon
背景和目的本研究旨在采用国际腹水俱乐部（伊卡）-阿基标准研究急性肾损伤（阿基）对腹膜炎患者自发性细菌性腹膜炎（SBP）长期死亡率的影响。方法回顾性分析2007 - 2016年157例首次发生SBP的住院患者的临床资料。我们研究了肝硬化SBP相关危险因素（包括ICA-AKI标准）的长期死亡率。SBP诊断时的ICA-AKI分期通过0-3期进行评价。分期进展定义为阿基进展至更高分期。结果SBP诊断时ICA-AKI分期0期91例（58%），1期33例（21%），2期19例（12%），3期14例（9%）。18例患者（12%）在SBP诊断后48小时内出现分期进展。多变量分析显示，总生存期的危险因素为年龄>= 60岁（风险比[HR] 1.74，P = 0.029）、血清钠
Background and Aim This study aimed to investigate the effect of acute kidney injury (AKI) on long-term mortality of spontaneous bacterial peritonitis (SBP) in cirrhotic patients using International Club of Ascites (ICA)-AKI criteria. Methods A total of 157 cirrhotic patients with a first episode of SBP between 2007 and 2016 were analyzed. We investigated the long-term mortality with related risk factors of SBP in cirrhosis including the ICA-AKI criteria. The ICA-AKI stage at SBP diagnosis is evaluated by stages 0-3. Stage progression was defined as a progression of AKI to a higher stage. Results The ICA-AKI stage at the diagnosis of SBP was stage 0 in 91 (58%), stage 1 in 33 (21%), stage 2 in 19 (12%), and stage 3 in 14 patients (9%). Stage progression within 48 h after SBP diagnosis was noted in 18 patients (12%). Multivariable analysis showed that the risk factors for overall survival were age >= 60 years (hazard ratio [HR] 1.74, P = 0.029), serum sodium