PREVALENCE OF HYPERTROPHIC CARDIOMYOPATHY IN A GENERAL-POPULATION OF YOUNG-ADULTS - ECHOCARDIOGRAPHIC ANALYSIS OF 4111 SUBJECTS IN THE CARDIA STUDY
PREVALENCE OF HYPERTROPHIC CARDIOMYOPATHY IN A GENERAL-POPULATION OF YOUNG-ADULTS - ECHOCARDIOGRAPHIC ANALYSIS OF 4111 SUBJECTS IN THE CARDIA STUDY
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DOI：
10.1161/01.cir.92.4.785
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发表时间：
1995-08-15
期刊：
影响因子：
37.8
通讯作者：
BILD, DE
中科院分区：
文献类型：
--
作者：
MARON, BJ;GARDIN, JM;BILD, DE
肥厚型心肌病（HCM）是一种遗传性疾病，是年轻人（包括竞技运动员）发病和心源性猝死的重要原因。然而，目前，很少有数据存在，以估计这种疾病的患病率在大population.Methods和结果的一部分，冠状动脉危险发展（年轻）成人（CARDIA）研究，一个流行病学研究的冠状动脉危险因素，1987年，从四个城市中心的普通人群中选出4111名23 - 35岁的男性和女性，进行了技术上令人满意的超声心动图检查直到1988年。7例受试者（0.17%）根据与全身性高血压无关的肥厚、非扩张左心室和最大室壁厚度大于或等于15 mm的鉴别结果，存在可能或明确的HCM超声心动图证据。男性和女性的患病率为0.26：0.09%;黑人和白人为0.24：0.10%。7例受试者的室间隔厚度为15 - 21 mm（平均17 mm）。7例受试者中仅1例曾出现HCM所致的重要心脏症状，既往怀疑患有心血管疾病或左心室流出道阻塞;其他4例受试者的二尖瓣收缩期前向运动相对轻微，不足以产生动态基底流出道阻塞。7例受试者中有5例ECG异常。其他五个研究对象的左心室壁厚度为15至21毫米，这是一个后果的全身hypertension.Conclusions肥厚型心肌病是目前在约2的1000名年轻人。这些独特的基于人群的数据将有助于评估HCM相关死亡率和发病率在普通人群中的影响，以及筛查HCM的大型人群（包括竞技运动员）的实用性。
Background Hypertrophic cardiomyopathy (HCM) is a genetically transmitted disease and an important cause of morbidity and sudden cardiac death in young people, including competitive athletes. At present, however, few data exist to estimate the prevalence of this disease in large populations.Methods and Results As part of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Study, an epidemiological study of coronary risk factors, 4111 men and women 23 to 35 years of age selected from the general population of four urban centers had technically satisfactory echocardiographic studies during 1987 through 1988. Probable or definite echocardiographic evidence of HCM was present in 7 subjects (0.17%) on the basis of identification of a hypertrophied, nondilated left ventricle and maximal wall thickness greater than or equal to 15 mm that were not associated with systemic hypertension. Prevalence in men and women was 0.26:0.09%; in blacks and whites, 0.24:0.10%. Ventricular septal thickness was 15 to 21 mm (mean, 17 mm) in the 7 subjects. Only 1 of the 7 subjects had ever experienced important cardiac symptoms attributable to HCM, had previously been suspected of having cardiovascular disease, or had obstruction to left ventricular outflow; 4 other subjects had relatively mild systolic anterior motion of the mitral valve that was insufficient to produce dynamic basal outflow obstruction. ECGs were abnormal in 5 of the 7 subjects. Five other study subjects had left ventricular wall thicknesses of 15 to 21 mm that were a consequence of systemic hypertension.Conclusions HCM was present in about 2 of 1000 young adults. These unique population-based data will aid in assessments of the impact of HCM-related mortality and morbidity in the general population and the practicality of screening large populations for HCM, including those comprising competitive athletes.