Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients
Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients
复制标题
DOI：
10.1016/j.atherosclerosis.2008.10.013
复制
发表时间：
2009-06-01
期刊：
影响因子：
5.3
通讯作者：
Nakazato, Masamitsu
中科院分区：
文献类型：
--
作者：
Yano, Yuichiro;Toshinai, Koji;Nakazato, Masamitsu
目的：即将到来的老年人肥胖流行需要建立新的和易于使用的心脏代谢标志物，以确定个人最有可能发展为动脉粥样硬化的高血压患者。方法：我们测定了血浆高分子量脂联素和去酰基生长素水平，和颈动脉内膜中层厚度（cIMT）在263名老年高血压患者（平均72.6岁，37%的男性）。其他心脏代谢标志物，包括代谢产物，炎症，止血，也measured.Results和conclusion：HMW脂联素和des-acyl ghrelin水平与肥胖呈负相关。高分子量脂联素水平与糖脂代谢产物派-1呈正相关（均P
Objective: The coming obesity epidemic in elderly persons necessitates the establishment of new and easy-to-use cardiometabolic markers to identify individuals most likely to develop atherosclerosis among hypertensives.Methods: We measured plasma HMW adiponectin and des-acyl ghrelin levels, and carotid-artery intima-media thickness (cIMT) in 263 elderly hypertensives (mean 72.6 years; 37%men). Other cardiometabolic markers, including metabolites, inflammation, and hemostasis, were also measured.Results and conclusion: Both HMW adiponectin and des-acyl ghrelin levels were inversely correlated with obesity. The HMW adiponectin level was favorably associated with glucose and lipid metabolites, PAI-1 (all P