Effect of weight loss on upper airway size and facial fat in men with obstructive sleep apnoea
Effect of weight loss on upper airway size and facial fat in men with obstructive sleep apnoea
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DOI：
10.1136/thx.2010.151613
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发表时间：
2011-09-01
期刊：
影响因子：
10
通讯作者：
Cistulli, Peter A.
中科院分区：
文献类型：
--
作者：
Sutherland, Kate;Lee, Richard W. W.;Cistulli, Peter A.
背景：阻塞性睡眠呼吸暂停（OSA）通常与肥胖有关，可以通过减肥来改善。与局部脂肪减少相关的上气道大小的改变可能介导OSA的改善。本研究旨在评估体重减轻时上呼吸道大小、局部面部和腹部脂肪的变化及其与OSA改善的关系。方法中重度阻塞性睡眠呼吸暂停的中年肥胖男性进行了为期24周的西布曲明辅助减肥试验。在基线和24周分别进行头颈部多导睡眠图和CT检查。用图像分析软件测量上呼吸道管腔、面部和咽旁脂肪。结果干预后患者体重显著减轻(-7.8+/-4.2 kg, p
Background Obstructive sleep apnoea (OSA) is commonly associated with obesity and can be improved by weight loss. Changes in upper airway size related to regional fat loss may mediate the improvement in OSA. This study aimed to assess changes in upper airway size and regional facial and abdominal fat with weight loss and their association with OSA improvement.Methods Middle-aged obese men with moderate-to-severe OSA underwent a 24-week sibutramine-assisted weight loss trial. Polysomnography and CT of the head and neck were performed at baseline and 24 weeks. The upper airway lumen and facial and parapharyngeal fat were measured with image analysis software.Results Post-intervention there was a significant reduction in weight (-7.8+/-4.2 kg, p