The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia
The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia
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匹伐他汀钙对高胆固醇血症所致内皮功能障碍的影响
DOI：
10.1517/14656566.2011.583238
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Yan HM, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH,
中科院分区：
文献类型：
--
作者：
Yan HM, Zhao J, Ma DZ, Wang H, Wang J, Wang ZH,
Objective: To investigate whether endothelial function can be improved by the treatment of pitavastatin calcium via its antioxidant properties in hypercholesteremia patients. Methods: Forty patients with hypercholesteremia were randomized to receive pitavastatin calcium 1 or 2 mg/day for 8 weeks. Among them, four people were lost in the follow-up period. Before and after treatment, clinical and biochemical characteristics, markers of oxidative stress (plasma 8-iso-prostaglandin F2α and serum gp91phox) were determined and concomitantly endothelium-dependent brachial artery flow-mediated dilation (FMD) was measured by ultrasound examination. Thirty healthy subjects were chosen as controls. Results: For individuals with hypercholesteremia, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and serum gp91phox were significantly increased (p < 0.001 for all) and plasma 8-iso-prostaglandinF2α (8-iso-PGF2α) was significantly higher (p < 0.05), while FMD was obviously impaired (p < 0.001). Total cholesterol, LDL-C and serum gp91phox were significantly reduced (p < 0.001 for all), plasma 8-iso-PGF2α was lower and FMD was significantly improved after pitavastatin calcium treatment compared with those before treatment in any group (p < 0.05 for both). However, there was no significant difference between the 1-mg and 2-mg pitavastatin calcium groups post-therapy. Conclusions: Endothelial dysfunction induced by hypercholesteremia can be ameliorated by pitavastatin calcium treatment, which occurs in part through its antioxidative properties.
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DOI：
10.1161/hq0202.104081
发表时间：
2002-02
期刊：
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association
影响因子：
--
作者：
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2006-11-01
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10.1016/s0140-6736(94)91755-8
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1994-10
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The Lancet
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G. Foster;M. Mittleman;Michael Koch;G. Abela;S. Zarich