Influenza revaccination of elderly travelers: Antibody response to single influenza vaccination and revaccination at 12 weeks
Influenza revaccination of elderly travelers: Antibody response to single influenza vaccination and revaccination at 12 weeks
复制标题
DOI：
10.1086/322013
复制
发表时间：
2001-07-15
影响因子：
6.4
通讯作者：
Hockin, J
中科院分区：
文献类型：
--
作者：
Buxton, JA;Skowronski, DM;Hockin, J
对健康老年人进行了单次接种流感疫苗的抗体应答和再次接种流感疫苗的效果评估。在旅行前接种过流感疫苗的大于或等于65岁的旅行者被登记在研究中，并在12周后接受第二次接种。地理位置和年龄匹配的对照受试者只接受了一次疫苗接种。第二次接种流感疫苗与不良反应增加无关。在28名对照组和28名重新接种疫苗的旅行者中，血凝素抑制(HI)抗体滴度对数(10)或HI抗体滴度大于或等于1：40(被认为是保护性的)之间没有显著差异。单次免疫和复种24周后，对甲型流感抗原的可能保护率仍然很高(A/悉尼/05/97[H3N2]，分别为92%和96%，A/Beijing/262/95[H1N1]，分别为80%和96%)。在整个研究过程中，对B/哈尔滨的反应较少。前5年接种次数越多，A/悉尼抗体滴度越低。因此，第二种疫苗并没有增强免疫反应。
The antibody response to a single influenza vaccination and the effect of influenza revaccination was assessed in healthy elderly persons. Travelers greater than or equal to 65 years old who had received influenza vaccine before travel were enrolled in the study and were offered a second vaccination after 12 weeks. Geographic and age-matched control subjects received a single vaccination. A second influenza vaccination was not associated with increased adverse effects. There was no significant difference between log(10) hemagglutinin-inhibiting (HI) antibody titers or an HI antibody titer greater than or equal to1:40 (considered to be protective) in 28 control subjects and 28 revaccinated travelers for any antigen. Probable protection for influenza A antigens remained high 24 weeks after a single immunization and revaccination (A/Sydney/05/97 [H3N2], 92% and 96%, and A/Beijing/262/95 [H1N1], 80% and 96%, respectively). Response to B/Harbin was less throughout the study. A/Sydney antibody titer was lower with more times vaccinated in the previous 5 years. Therefore, a second vaccine did not enhance the immune response.