Elevated peptide YY levels in adolescent girls with anorexia nervosa
Elevated peptide YY levels in adolescent girls with anorexia nervosa
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DOI：
10.1210/jc.2005-1878
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发表时间：
2006-03-01
影响因子：
5.8
通讯作者：
Klibanski, A
中科院分区：
文献类型：
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作者：
Misra, M;Miller, KK;Klibanski, A
背景：肽YY （PYY）是一种肠源性厌氧素，通过Y2受体起作用，而在啮齿类动物中，Y2受体缺失会增加骨形成。神经性厌食症（AN）与故意减少食物摄入和低骨密度有关，但AN中食物摄入的内分泌调节因子尚不清楚。此外，已知的骨转换调节因子，如生长激素、皮质醇和雌激素，只能解释骨转换标志物水平变化的一小部分。假设：我们假设与对照组相比，PYY可能在AN中升高，并可能导致食物摄入减少和骨形成。方法：对23例AN女孩和21例12 ~ 18岁健康青少年进行空腹PYY检测。我们还检查了生长激素、皮质醇、胃促生长素和瘦素（夜间频繁取样）和空腹igf - 1、雌二醇、总T-3和骨标志物。测定各组常量营养素摄入量和静息能量消耗（REE）。结果：与对照组相比，AN女孩PYY水平较高（17.8 +/- 10.2 vs. 4.8 +/- 4.3 pg/ml; P < 0.0001）。log PYY的预测因子是营养指标，包括体重指数（r = -0.62; P < 0.0001）、脂肪量（r = -0.55; P = 0.0003）和REE (r = -0.51; P = 0.0006)，激素指标，包括生长激素（r = 0.38; P = 0.004）和T-3 （r = -0.59; P = 0.0001）。体重指数、脂肪量、REE、GH和T-3解释了log PYY 68%的变异性。Log PYY预测来自脂肪的卡路里百分比（r = -0.56; P = 0.0002），独立预测骨钙素（r = -0.45; P = 0.003）、骨特异性碱性磷酸酶（r = -0.46; P = 0.003）、n -末端肽/肌酐（r = -0.55; P = 0.0003）和脱氧吡啶啉/肌酐（r = -0.52; P = 0.001）的回归模型。结论：PYY升高可能导致AN患者摄入减少和骨转换减少。
Background: Peptide YY (PYY) is an intestinally derived anorexigen that acts via the Y2 receptor, and Y2 receptor deletion in rodents increases bone formation. Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators of food intake in AN are not known. In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels.Hypotheses: We hypothesized that PYY may be elevated in AN compared with controls and may contribute to decreased food intake and bone formation.Methods: Fasting PYY was examined in 23 AN girls and 21 healthy adolescents 12-18 yr old. We also examined GH, cortisol, ghrelin, and leptin (overnight frequent sampling) and fasting IGF-I, estradiol, total T-3, and bone markers. Macronutrient intake and resting energy expenditure (REE) were measured.Results: AN girls had higher PYY levels compared with controls (17.8 +/- 10.2 vs. 4.8 +/- 4.3 pg/ml; P < 0.0001). Predictors of log PYY were nutritional markers, including body mass index (r = -0.62; P < 0.0001), fat mass (r = -0.55; P = 0.0003), and REE (r = -0.51; P = 0.0006), and hormones, including GH (r = 0.38; P = 0.004) and T-3 (r = -0.59; P = 0.0001). Body mass index, fat mass, REE, GH, and T-3 explained 68% of the variability of log PYY. Log PYY predicted percentage of calories from fat (r = -0.56; P = 0.0002) and independently predicted osteocalcin (r = -0.45; P = 0.003), bone-specific alkaline phosphatase (r = -0.46; P = 0.003), N-telopeptide/creatinine (r = -0.55; P = 0.0003), and deoxypyridinoline/creatinine (r = -0.52; P = 0.001) on regression modeling.Conclusion: Elevated PYY may contribute to reduced intake and decreased bone turnover in AN.