The physiology of Phosphoinositides
The physiology of Phosphoinositides
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DOI：
10.1248/bpb.30.1599
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发表时间：
2007-09-01
影响因子：
2
通讯作者：
Suzuki, Akira
中科院分区：
文献类型：
--
作者：
Sasaki, Takehiko;Sasaki, Junko;Suzuki, Akira
磷酸肌醇是膜脂磷脂酰肌醇的磷酸化衍生物家族。这些脂质高度集中在位于细胞膜、核内体或细胞核内的不同池中，在那里它们作为磷酸或非甾体苷结合蛋白的配体起作用。结合磷酸肌苷的蛋白结构域包括pleckstrin homology （PH）结构域、phox homology （PX）结构域和Fab1pYOPB-Vps27p-EEA1 （FYVE）结构域。这些结构域存在于许多参与细胞内信号传导、膜运输和细胞骨架重排的蛋白质中。最近的研究已经确定了涉及磷酸肌苷的各种信号通路的改变与许多人类疾病的病因之间的潜在联系。
Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for p hosph o i nositide-bin ding proteins. Protein domains that bind phosphoinositides include the pleckstrin homology (PH) domain, the phox homology (PX) domain and the Fab1pYOPB-Vps27p-EEA1 (FYVE) domain. These domains are found in many proteins involved in intracellular signaling, membrane trafficking and cytoskeletal rearrangement. Recent studies have identified potential links between alterations to various signaling pathways involving phosphoinositides and the etiology of many human diseases.