Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin
Comparative study of treatment efficacy and the incidence of post-inflammatory hyperpigmentation with different degrees of irradiation using two different quality-switched lasers for removing solar lentigines on Asian skin
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DOI：
10.1111/j.1468-3083.2011.04385.x
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发表时间：
2013-03-01
影响因子：
9.2
通讯作者：
Matsunaga, K.
中科院分区：
文献类型：
--
作者：
Negishi, K.;Akita, H.;Matsunaga, K.
背景质量开关（QS）激光是众所周知的去除日光性雀斑的有效治疗方法。然而，炎症后色素沉着过度（PIH）的高发病率引起了对深色皮肤类型的关注。这是第一项比较两种QS激光器不同照射程度对亚洲皮肤的疗效和PIH发生率的研究。方法将193例355个Ⅲ Ⅳ型日光性雀斑患者随机分为4组。所有病例均接受单次激光治疗。4周后评价临床疗效。第1组和第3组进行积极治疗，终点为病变非常明显的立即变白（IW）。第2组和第4组接受轻度治疗，终点为病变轻微IW。第1、2组用QS红宝石激光照射，第3、4组用QS倍频Nd：YAG激光照射。结果四组间的清除程度差异无统计学意义。妊高征发生率在第1、2、3、4组分别为33.33%、7.47%、23.18%、8.47%。积极照射组和轻度照射组（1和3 vs. 2和4）之间的差异有统计学意义（P
Background Quality-switched (QS) lasers are well-known effective treatment for removing solar lentigines. However, the high incidence of post-inflammatory hyperpigmentation (PIH) raises concern in darker skin types. This is the first study comparing efficacies and incidences of PIH in Asian skin with different degrees of irradiation between two QS lasers. Method In total, 355 solar lentigines in 193 cases, skin types IIIV, were randomly divided into four groups. All cases received single laser treatment. Clinical results were evaluated after 4weeks. Groups 1 and 3 were treated aggressively' with endpoints of very obvious immediate whitening (IW) of the lesion. Groups 2 and 4 were treated mildly' with endpoints of slight IW of the lesion. Groups 1 and 2 were irradiated with the QS ruby, and groups 3 and 4 with the QS frequency doubled Nd:YAG laser. Results There were no statistically significant differences in degrees of clearance among the four groups. However, PIH incidences were very different: 33.33%, 7.47%, 23.18% and 8.47% in groups 1, 2, 3 and 4 respectively. The difference between aggressively and mildly irradiated groups (1 and 3 vs. 2 and 4) was statistically significant (P