Significance of serum IgA levels and serum IgA/C3 ratio in diagnostic analysis of patients with IgA nephropathy
Significance of serum IgA levels and serum IgA/C3 ratio in diagnostic analysis of patients with IgA nephropathy
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DOI：
10.1002/jcla.10071
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发表时间：
2003-01-01
影响因子：
2.7
通讯作者：
Tomino, Y
中科院分区：
文献类型：
--
作者：
Maeda, A;Gohda, T;Tomino, Y
描述了 IgA 肾病患者血清 IgA 水平和血清 IgA/C3 比值等临床标志物的诊断分析。 IgA肾病患者100例（IgA肾病组）和其他原发性肾小球疾病患者100例（非IgA肾病组）。进行了检查。使用四种临床标志物进行分析以区分这两组：1) 尿沉渣中超过 5 个红细胞，2) 持续性蛋白尿（尿蛋白超过 0.3 g/天），3) 血清 IgA 水平超过 315 mg/dl，以及 4) 血清 IgA/C3 比率超过 3.01。在本研究中，具有三到四种临床标志物的患者很容易被诊断为患有 IgA 肾病。此外，IgA肾病患者的预后良好组和预后相对较好组（I组和II组）与预后相对较差组和预后不良组（III组和IV组）之间这些临床标志物存在显着差异。镜下血尿和/或持续性蛋白尿的存在、高血清 IgA 水平以及血清 IgA/C3 比值似乎有助于区分 IgA 肾病与其他原发性肾脏疾病。据推测，这些临床标志物也可用于无需肾活检的 IgA 肾病诊断。 (C) 2003 Wiley-Liss, Inc.
Diagnostic analysis of clinical markers including serum IgA levels and serum IgA/C3 ratio in patients with IgA nephropathy is described. One hundred patients with IgA nephropathy (IgA nephropathy group) and 100 patients with other primary glomerular diseases (non-IgA nephropathy group). were examined. The analysis was performed to distinguish between these two groups using four clinical markers: 1) more than five red blood cells in urinary sediments, 2) persistent proteinuria (urinary protein of more than 0.3 g/day), 3) serum IgA levels of more than 315 mg/dl, and 4) a serum IgA/C3 ratio of more than 3.01. Patients with three or four clinical markers were easily diagnosed as having IgA nephropathy in this study. Furthermore, there was a significant difference in these clinical markers between the good prognosis and relatively good prognosis groups (Groups I and II) and the relatively poor prognosis and poor prognosis groups (Groups III and IV) of IgA nephropathy patients. It appears that the presence of microscopic hematuria and/or persistent proteinuria, high serum IgA levels, and the serum IgA/C3 ratio are useful for distinguishing IgA nephropathy from other primary renal diseases. It is postulated that these clinical markers are also useful for diagnosis of IgA nephropathy without renal biopsy. (C) 2003 Wiley-Liss, Inc.