Differential effects of ethanol on memory in adolescent and adult rats
Differential effects of ethanol on memory in adolescent and adult rats
复制标题
DOI：
10.1111/j.1530-0277.1998.tb03668.x
复制
发表时间：
1998-04-01
影响因子：
3.2
通讯作者：
Swartzwelder, HS
中科院分区：
文献类型：
--
作者：
Markwiese, BJ;Acheson, SK;Swartzwelder, HS
先前的研究表明，与成年大鼠相比，乙醇对未成熟大鼠海马片中与记忆相关的突触活动和可塑性的抑制作用更强。因此，我们假设，与成年大鼠相比，乙醇将更有效地减弱青少年空间记忆的获得，成年(65天龄)和青少年(30天龄)雄性大鼠在Morris水迷宫中进行空间记忆任务的每日活体试验。每个年龄组的动物被细分为三个亚组。每天训练前30min，各亚组动物分别腹腔注射1.0g/kg乙醇、2.0g/CG乙醇或生理盐水。每天继续训练，直到对照动物达到表现标准。乙醇处理显著损害了青春期大鼠的空间记忆习得，但对成年大鼠的习得没有影响。另一项针对相同治疗组的单独实验表明，乙醇不会损害两个年龄段的动物在水迷宫中非空间记忆任务的获得。这些实验表明，与成年动物相比，酒精对青春期动物的空间记忆(但不是非空间记忆)获得的损害更大。
Previous studies have shown that ethanol inhibits memory-related synaptic activity and plasticity more potently in hippocampal slices from immature rats, compared with those taken from adults. We therefore hypothesized that ethanol would more potently attenuate the acquisition of spatial memory in adolescents, compared with adult rats, Adult (65 days of age) and adolescent (30 days of age) male rats were given live daily trials on a spatial memory task in a Morris Water Maze. The animals from each age group were subdivided into three subgroups. Each day, thirty minutes before training, the animals in each subgroup were given an intraperitoneal injection of 1.0 g/kg of ethanol, 2.0 g/cg of ethanol, or the saline vehicle. Training continued daily until the control animals had reached a performance criterion. Ethanol treatment significantly impaired spatial memory acquisition in the adolescent rats, but did not impair acquisition in adult rats. A separate experiment with identical treatment groups showed that ethanol did not impair acquisition of a nonspatial memory task In the water maze in animals from either age group. These experiments show that the acquisition of spatial, but not nonspatial, memory is more potently impaired by ethanol in adolescent animals, compared with adults.