Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function
Fluid-solid coupling for the investigation of diastolic and systolic human left ventricular function
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DOI：
10.1002/cnm.1405
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发表时间：
2011-07-01
影响因子：
2.1
通讯作者：
Smith, N. P.
中科院分区：
文献类型：
--
作者：
Nordsletten, D.;McCormick, M.;Smith, N. P.
了解流体/固体耦合的潜在反馈机制及其在心脏功能中发挥的作用对于表征正常心脏功能及其在疾病中的行为至关重要。为了提高这种理解，提出了左心室流固力学的解剖学精确计算模型，该模型评估心脏的被动舒张期和主动收缩期。整合表征心脏血流动力学和组织机械特性的多个数据，应用数值方法，允许最佳有限元方案中的不一致性（J. Comp. Phys.，提交；左心室力学模拟的流固耦合，牛津大学，2009 年）。该方法专门用于观察左心室流体/固体耦合，从而可以定量评估通过左心室的血流、压力分布、激活以及由于粘性耗散而导致的机械能损失。版权所有 (C) 2010 约翰·威利父子有限公司
Understanding the underlying feedback mechanisms of fluid/solid coupling and the role it plays in heart function is crucial for characterizing normal heart function and its behavior in disease. To improve this understanding, an anatomically accurate computational model of fluid-solid mechanics in the left ventricle is presented which assesses both the passive diastolic and active systolic phases of the heart. Integrating multiple data which characterize the hemodynamical and tissue mechanical properties of the heart, a numerical approach was applied which allows non-conformity in an optimal finite element scheme (J. Comp. Phys., submitted; Fluid-solid coupling for the simulation of left ventricular mechanics, University of Oxford, 2009). This approach is applied to look specifically at left ventricular fluid/solid coupling, allowing quantitative assessment of blood flow through the left ventricle, pressure distributions, activation and the loss of mechanical energy due to viscous dissipation. Copyright (C) 2010 John Wiley & Sons, Ltd.