Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis:: Potential connection between carbon and nitrogen metabolism
Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis:: Potential connection between carbon and nitrogen metabolism
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DOI：
10.1128/jb.187.19.6856-6861.2005
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发表时间：
2005-10-01
影响因子：
3.2
通讯作者：
Saier, MH
中科院分区：
文献类型：
--
作者：
Choi, SK;Saier, MH
在枯草芽孢杆菌编码sigma(L)的sigL结构基因中发现了CcpA转录因子结合位点分解代谢反应元件（CRE）。研究表明，CcpA结合该CRE通过“路障”机制调节sigL表达，该机制部分解释了分解代谢抑制sigma(L)导向的levD操纵子表达的原因。
A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding sigma(L) in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a "roadblock" mechanism and that this mechanism in part accounts for catabolite repression of sigma(L)-directed levD operon expression.