Local cerebral metabolic rates of glucose in movement and language disorders from positron tomography.
Local cerebral metabolic rates of glucose in movement and language disorders from positron tomography.
复制标题
正电子断层扫描显示运动和语言障碍中葡萄糖的局部脑代谢率。
DOI：
10.1152/ajpregu.1984.246.6.r897
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Kuhl,DE
中科院分区：
文献类型：
--
作者：
Metter,EJ;Riege,WH;Hanson,WR;Phelps,ME;Kuhl,DE
用[18F]氟脱氧葡萄糖测量葡萄糖代谢的正电子计算机断层扫描显示了远离梗死灶区域的大脑变化，表明局灶性异常表现为更广泛的功能过程。提出了几种方法，以更好地了解定量代谢数据，并专注于尾状核和基底神经节的功能。帕金森病和亨廷顿病患者的区域与区域相关性显示，与对照组相比，皮质关系的数量减少，这表明基底神经节与皮质区域共同发挥功能的能力有关。在失语症中，尾状核代谢与几种语言测量相关，这些测量表明在一些未定义的基本过程中发挥作用，似乎与布罗卡区功能有关。提出的研究表明，尾状核可能涉及整合语言和认知的处理与执行所产生的反应。运动和认知功能似乎与相似和重叠的大脑系统有关。这些系统的破坏可能导致功能的认知和运动方面的丧失。
Positron-computed tomography with [18F]fluorodeoxyglucose to measure glucose metabolism has shown changes in the brain distant to a focal area of infarction, demonstrating that what appears as a focal abnormality represents a more widespread functional process. Several approaches are presented to better understand quantitative metabolic data and focus on caudate and basal ganglia function. Area-to-area correlations in Parkinson's and Huntington's diseases showed decreases in the number of cortical relationships compared with control subjects, suggesting that the basal ganglia are involved with the ability of cortical regions to function together. In aphasia, caudate metabolism correlated with several language measures that suggested a role in some undefined basic process, seemingly related to Broca's area function. The studies presented suggest that the caudate may involve integrating the processing of language and cognition with the execution of the resulting response. Motor and cognitive function seem related to similar and overlapping brain systems. The disruption of such systems may result in loss of both cognitive and motor aspects of a function.