Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series
Dermoscopy of Melanocytic Lesions in Patients Affected by Oculocutaneous Albinism: A Case Series
复制标题
眼皮肤白化病患者黑素细胞病变的皮肤镜检查：病例系列
作者：
G. Caldarola;L. Fania;B. Fossati;A. Zampetti;P. Broganelli;G. Massi;C. Feliciani
背景：虽然白化病患者的大多数皮肤癌由鳞状细胞癌和基底细胞癌组成，但也有恶性黑色素瘤的报道，尽管频率较低。目的：我们研究的目的是评估白化病患者的黑素细胞病变，以寻找任何复发的皮肤镜模式。方法：我们连续招募了 12 名来我们科室就诊的白化病患者，并用肉眼检查每位患者是否存在黑素细胞痣，然后进行皮肤镜检查。切除具有可疑临床或皮肤镜特征的黑素细胞病变并进行组织病理学评估。结果：通过对记录图像的分析，我们发现了这组患者的两种主要皮肤镜模式。第一个表现为均匀的浅棕色淡黄色图案，伴有逗号状和点状血管；第二个由经典的棕色网状图案组成，通常与中央脱色和逗号状血管相关。此外，根据一些非典型皮肤镜特征，我们在 2 名患者中原位切除了 3 个黑色素瘤（同一患者）和一个较厚的黑色素瘤（3.2 毫米）。结论：皮肤镜检查可能是评估白化病患者黑色素细胞病变的有用工具，可以早期诊断黑色素瘤。
Background: Although the majority of skin cancers in albino patients consists of squamous and basal cell carcinomas, malignant melanomas have also been described, albeit less frequently. Objective: The aim of our study was to evaluate melanocytic lesions in albino patients to look for any recurrent dermoscopic pattern. Methods: We enrolled 12 consecutive albino patients presenting to our department and examined each patient for the presence of melanocytic nevi with the unaided eye and then with dermoscopy. Melanocytic lesions with suspicious clinical or dermoscopic features were excised and histopathologically evaluated. Results: Analysis of the recorded images permitted us to find two main dermoscopic patterns in this group of patients. The first one was represented by a homogeneous light-brown yellowish pattern associated with comma-like and dotted vessels; the second one consisted of a classical brown reticular pattern frequently associated with central depigmentation and with comma-like vessels. Moreover, based on some atypical dermoscopic features, in 2 patients we excised 3 melanomas in situ (in the same patient) and a thick melanoma (3.2 mm). Conclusions: Dermoscopy may represent a useful tool for the evaluation of melanocytic lesions in albino patients, permitting an early diagnosis of melanoma.
在缺乏功能性酪氨酸酶的情况下皮肤无色素性黑色素瘤的发展。
DOI：
10.1034/j.1600-0749.2001.140607.x
发表时间：
2001
期刊：
Pigment cell research
影响因子：
--
作者：
Cohen-Solal,KA;Reuhl,KR;Ryan,KB;Roberts,KG;Chen,S
通讯作者：
Chen,S