Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up
Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele epsilon 4 during 14 months follow-up
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DOI：
10.1016/0304-3940(96)12905-0
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发表时间：
1996-08-23
影响因子：
2.5
通讯作者：
Wahlund, LO
中科院分区：
文献类型：
--
作者：
Blomberg, M;Jensen, M;Wahlund, LO
在阿尔茨海默病（AD）的脑脊液（CSF）中tan蛋白的浓度升高，表明CSF tau可能是这种疾病的有用的生化诊断标志物。我们通过ELISA（Innotest hTau Antigen（R），Innogenetics，Belgium）在AD（n = 18）、轻度认知障碍（MCI，n = 9）和其他痴呆疾病（OD，n = 9）中两次研究CSF tau浓度。在两种情况下，AD组中的Tau水平在统计学上显著高于MCI和OD组。12例AD患者在随访时显示tau值增加，6例显示tau值减少。所有晒黑程度增加的AD患者均携带一个或两个载脂蛋白E（APOE）基因的等位基因。在tau蛋白水平降低的AD病例中，只有3个个体具有α 4等位基因，差异具有统计学显著性（P < 0.05）。这些结果表明，可能有载脂蛋白E（apoE）异构体的具体差异，在AD的tan调节。
The concentration of tan protein is elevated in the cerebrospinal fluid (CSF) in Alzheimer's disease (AD), suggesting that CSF tau may be a useful biochemical diagnostic marker for this disorder. We investigated CSF tau concentrations on two occasions in AD (n = 18), mild cognitive impairment (MCI, n = 9) and other dementing diseases (OD, n = 9) by ELISA (Innotest hTau Antigen(R), Innogenetics, Belgium). Tau levels were statistically significant higher in the AD group than in MCI and OD groups on both occasions. Twelve of the AD patients showed increasing values of tau at follow-up and six demonstrated diminished values. All AD patients with increasing tan were carriers of one or two epsilon 4 alleles of the apolipoprotein E (APOE) gene. Of those AD cases with decreasing tau levels only three individuals had the epsilon 4 allele, a difference that was statistically significant (P < 0.05). These findings suggest that there may be apolipoprotein E (apoE) isoform-specific differences of tan regulation in AD.