Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure.
Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure.
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DOI：
10.1155/2016/2579832
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发表时间：
2016
影响因子：
2.1
通讯作者：
Lombardi F
中科院分区：
文献类型：
--
作者：
Galli A;Lombardi F
心力衰竭是一种发病率和死亡率很高的慢性疾病，对医学界提出了越来越大的挑战。射血分数降低的心力衰竭的一个主要危险因素是心肌梗死病史。大面积梗死瘢痕的扩大和随后的局部心室扩张可引起梗死后重构，导致左心室腔显著扩大。它具有负面的预后价值，因为它先于心力衰竭的临床表现。预测梗死后重构的梗死心肌的特征可以用心脏磁共振研究，并且实验成像方式如扩散张量成像可以识别心肌纤维结构的变化。本文综述了与梗死后左室重构相关的所有方面：定义、发病机制、诊断、后果和可用的治疗方法，以及对梗死后左室重构和心力衰竭显示出有希望结果的实验干预措施。
Heart failure is a chronic disease with high morbidity and mortality, which represents a growing challenge in medicine. A major risk factor for heart failure with reduced ejection fraction is a history of myocardial infarction. The expansion of a large infarct scar and subsequent regional ventricular dilatation can cause postinfarct remodelling, leading to significant enlargement of the left ventricular chamber. It has a negative prognostic value, because it precedes the clinical manifestations of heart failure. The characteristics of the infarcted myocardium predicting postinfarct remodelling can be studied with cardiac magnetic resonance and experimental imaging modalities such as diffusion tensor imaging can identify the changes in the architecture of myocardial fibers. This review discusses all the aspects related to postinfarct left ventricular remodelling: definition, pathogenesis, diagnosis, consequences, and available therapies, together with experimental interventions that show promising results against postinfarct remodelling and heart failure.