EFFECTS OF CAFFEINE ON PLASMA-RENIN ACTIVITY, CATECHOLAMINES AND BLOOD-PRESSURE
EFFECTS OF CAFFEINE ON PLASMA-RENIN ACTIVITY, CATECHOLAMINES AND BLOOD-PRESSURE
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DOI：
10.1056/nejm197801262980403
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发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
OATES, JA
中科院分区：
文献类型：
--
作者：
ROBERTSON, D;FROLICH, JC;OATES, JA
采用双盲、随机、交叉方案，在整个研究期间保持 Na 平衡的 9 名健康、年轻、不喝咖啡的人中研究了单剂量口服咖啡因对血浆肾素活性、儿茶酚胺和心血管控制的影响。将咖啡因（250 毫克）或安慰剂放入不含甲基黄嘌呤的饮料中，给予前 3 周未喝过咖啡、茶或可乐的过夜禁食仰卧受试者。咖啡因使血浆肾素活性增加 57%，血浆去甲肾上腺素活性增加 75%，血浆肾上腺素活性增加 207%。尿去甲肾上腺素和变肾上腺素分别增加 52% 和 100%。摄入咖啡因后 1 小时平均血压上升 14/10 mm Hg。心率先是略有下降，然后又上升。血浆咖啡因水平通常在摄入后 1 小时达到最高，但个体间存在相当大的差异。呼吸频率增加 20% 与血浆咖啡因水平密切相关。在研究条件下，咖啡因是血浆肾素活性和肾上腺髓质分泌的有效刺激剂。习惯性摄入是否具有类似的影响仍有待确定。
Using a double-blind, randomized, crossover protocol, the effect of a single dose of oral caffeine on plasma renin activity, catecholamines and cardiovascular control was studied in 9 healthy, young, non-coffee drinkers maintained in Na balance throughout the study period. Caffeine (250 mg) or placebo was administered in a methylxanthine-free beverage to overnight-fasted supine subjects who had had no coffee, tea or cola in the previous 3 wk. Caffeine increased plasma renin activity by 57%, plasma norepinephrine by 75% and plasma epinephrine by 207%. Urinary normetanephrine and metanephrine were increased 52% and 100%, respectively. Mean blood pressure rose 14/10 mm Hg 1 h after caffeine ingestion. There was a slight fall and then a rise in heart rate. Plasma caffeine levels were usually maximal 1 h after ingestion but there was considerable interindividual variation. A 20% increase in respiratory rate correlated well with plasma caffeine levels. Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion. Whether habitual ingestion has similar effects remains to be determined.