Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of non-steroidal anti-inflammatory drugs (NSAIDs)
Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of non-steroidal anti-inflammatory drugs (NSAIDs)
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DOI：
10.1248/cpb.53.524
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发表时间：
2005-05-01
影响因子：
1.7
通讯作者：
Omata, K
中科院分区：
文献类型：
--
作者：
Fujisawa, H;Fujiwara, T;Omata, K
报道了光学活性2-芳基-2-氟丙酸2的合成。2-芳基-2-氟丙酸是2-芳基丙酸的非异构化模拟物，2-芳基丙酸是一类广泛应用于非甾体抗炎药的化合物。这是我们的研究的继续，涉及手性含氟有机分子作为药用重要化合物的有效类似物的设计、合成和评价。
We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.