A burst of c-fos gene expression in the mouse occurs at birth
A burst of c-fos gene expression in the mouse occurs at birth
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小鼠出生时 c-fos 基因突然表达
DOI：
10.1128/mcb.7.9.3349-3352.1987
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发表时间：
1987
影响因子：
5.3
通讯作者：
K. Ozato
中科院分区：
文献类型：
--
作者：
J. Kasik;Y. Wan;K. Ozato
本文研究了小鼠围产期发育过程中c-fos基因的表达。出生前，所有8个产前器官检测表达检测不到或低水平的c-fos mRNA。在出生当天，所有这些器官中的c-fos信息水平都增加了10到100倍。c-fos mRNA的表达是短暂的，在生后1d，其表达水平急剧下降。出生时c-fos基因的表达与c-myc基因和主要组织相容性复合体I类基因的表达无关，这两种基因在围产期发育过程中表现出不同的动力学。c-fos基因在分娩前1 ~ 2天的妊娠子宫中也有局部和短暂的表达。这些结果表明，与出生相关的事件诱导了母亲和新生儿中c-fos基因的表达。
Expression of the c-fos gene during murine perinatal development was studied. Before birth, all eight of the prenatal organs tested expressed undetectable or low levels of c-fos mRNA. On the day of birth, there occurred a 10- to 100-fold increase in the level of c-fos message in all of these organs. The expression was transient, in that 1 day after birth, the level of c-fos mRNA precipitously dropped. The c-fos gene expression at birth is unrelated to the expression of the c-myc gene and major histocompatibility complex class I genes, which display distinct kinetics during the perinatal development. The c-fos gene was also expressed locally and transiently in the gravid uterus 1 to 2 days prior to delivery. These results indicate that an event associated with birth induced c-fos gene expression in the mother and newborn.