THE ANATOMY OF MELANCHOLIA - FOCAL ABNORMALITIES OF CEREBRAL BLOOD-FLOW IN MAJOR DEPRESSION
THE ANATOMY OF MELANCHOLIA - FOCAL ABNORMALITIES OF CEREBRAL BLOOD-FLOW IN MAJOR DEPRESSION
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DOI：
10.1017/s003329170003806x
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发表时间：
1992-08-01
影响因子：
6.9
通讯作者：
DOLAN, RJ
中科院分区：
文献类型：
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作者：
BENCH, CJ;FRISTON, KJ;DOLAN, RJ
应用正电子发射断层扫描(PET)和氧分压测定了33例抑郁症患者(其中10例伴有严重认知功能障碍)和23例年龄匹配的对照组的局部脑血流量(RCBF)。在逐个像素的基础上对这些组的PET扫描进行了分析，并在统计参数图(SPM)上确定了组之间的显著差异。整体而言，抑郁组左侧扣带回前部和左侧前额叶背外侧皮质局部脑血流量降低(P<；0~05Bonferroni，经多次比较校正)。比较有无抑郁相关认知损害的患者，受损组左侧额内侧回的rCBF显著降低，小脑疣部的rCBF显著增加(P<；0.05 Bonferroni校正)。因此，已经描述了与抑郁情绪和抑郁相关的认知损害相关的rCBF特征之间的解剖学分离。这项研究中确定的额叶前区和边缘区域构成了一个分布的解剖网络，在严重抑郁障碍中可能存在功能异常。
Using positron emission tomography( PET) and Oxygen-15, regional cerebral blood flow (rCBF) was measured in 33 patients with primary depression, 10 of whom had an associated severe cognitive impairment, and 23 age-matched controls. PET scans from these groups were analysed on a pixel-by-pixel basis and significant differences between the groups were identified on Statistical Parametric Maps (SPMs). In the depressed group as a whole rCBF was decreased in the left anterior cingulate and the left dorsolateral prefrontal cortex (P < 0-05 Bonferroni-corrected for multiple comparisons). Comparing patients with and without depression-related cognitive impairment, in the impaired group there were significant decreases in rCBF in the left medial frontal gyrus and increased rCBF in the cerebellar vermis (P < 0.05 Bonferroni-corrected). Therefore an anatomical dissociation has been described between the rCBF profiles associated with depressed mood and depression-related cognitive impairment. The pre-frontal and limbic areas identified in this study constitute a distributed anatomical network that may be functionally abnormal in major depressive disorder.