Plasma surfactant D in patients following acute paraquat intoxication
Plasma surfactant D in patients following acute paraquat intoxication
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DOI：
10.1080/15563650701338138
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Hong, Sae-Yong
中科院分区：
文献类型：
--
作者：
Gil, Hyo-Wook;Hong, Jung-Rock;Hong, Sae-Yong
Free radical-induced lung injury is a major problem that occurs because of paraquat intoxication. Serum surfactant protein D (SP-D) reflects the severity of various lung diseases. The purpose of this study is to investigate the changes in plasma SP-D concentrations and to correlate disease severity with SP-D concentrations in patients with acute paraqaut intoxication. Twelve paraquat-intoxicated patients participated in this study. Their paraquat exposure was assessed by their plasma's paraquat level. Serial plasma SP-Ds were measured by ELISA. SP-D was decreased two and three days after the initial measurement within 2 to 72 hours of ingestion. There was no difference in initial SP-D levels between survivors and non-survivors. The SP-D test revealed a significant positive correlation between the SP-D level and PaO2 (r = 0.384, p = 0.003, N = 57). SP-D did not predict the likelihood of survival, but it was positively correlated with PaO2. This finding suggests that low concentrations of plasma SP-D could reflect hypoxia due to free radical-induced injury.
