Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris
Concentrations of interleukins, interferon, and C-reactive protein in stable and unstable angina pectoris
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DOI：
10.1016/s0002-9149(02)03097-7
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发表时间：
2003-01-15
影响因子：
2.8
通讯作者：
Daida, H
中科院分区：
文献类型：
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作者：
Yamashita, H;Shimada, K;Daida, H
我们分析了 40 名不稳定型心绞痛 (UAP) 患者、39 名稳定型心绞痛 (SAP) 患者以及 52 名年龄和性别匹配的对照者中白介素 (IL)-6、IL-10、IL-12 和 IL-18、干扰素 (IFN)-gamma 和高敏 C 反应蛋白 (hsCRP) 的浓度。与对照组相比，SAP组和UAP组的IL-12浓度均显着升高，尤其是UAP组，且UAP组的IL-18浓度趋于升高。相反，SAP 和 UAP 组的 IL-10 浓度显着较低。 UAP 组中 IL-6 和 hsCRP 浓度均显着升高。 ,hsCRP水平与炎症或促炎细胞因子（IL-6、IL-12和IL-18）呈正相关，与抗炎细胞因子（IL-10）呈负相关。此外，IL-12的水平与IL-18呈正相关，与IL-10呈负相关，结果揭示了T-helper I的显性状态。这些结果表明炎症反应与冠状动脉粥样硬化和心绞痛密切相关，并且T辅助蛋白1的优势可能在这些疾病中发挥重要作用。 (C)2003，Excerpta Medica, Inc.
We analyzed the concentrations of interleukins (IL)-6, IL-10, IL-12, and IL-18, interferon (IFN)-gamma, and high-sensitivity C-reactive protein (hsCRP) in 40 patients with unstable angina (UAP), 39 patients with stable angina (SAP), and 52 age- and gender-matched controls. Compared with the control group, IL-12 concentrations were significantly higher in both the SAP and UAP groups, especially in the UAP group, and the IL-18 concentrations tended to be higher in the UAP group. Conversely, IL-10 concentrations were significantly lower in the SAP and UAP groups. Both IL-6 and hsCRP concentrations were significantly higher in the UAP group. The levels of ,hsCRP were positively correlated with inflammatory or proinflammatory cytokines (IL-6, IL-12, and IL-18), and negatively correlated with anti-inflammatory cytokine (IL-10). Moreover, the levels of IL-12 were positively correlated with IL-18, and negatively correlated with IL-10, and the results revealed the T-helper I dominant state. These results suggested that the inflammatory response was strongly associated with coronary atherosclerosis and angina pectoris, and that the T-helper 1 dominance may play an important role in these diseases. (C)2003 by Excerpta Medica, Inc.