The power, pitfalls and potential of the nanodisc system for NMR-based studies
The power, pitfalls and potential of the nanodisc system for NMR-based studies
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DOI：
10.1515/hsz-2016-0224
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发表时间：
2016-12-01
影响因子：
3.7
通讯作者：
Etzkorn, Manuel
中科院分区：
文献类型：
--
作者：
Viegas, Aldino;Viennet, Thibault;Etzkorn, Manuel
选择合适的膜模拟环境对于表征膜蛋白的结构和功能至关重要。在这方面，脂质双层纳米盘技术的使用为基于核磁共振（NMR）的研究提供了独特的潜力。本文综述了这一领域的最新进展，重点是（一）系统的优势，（二）可能面临的瓶颈，（三）有前途的能力，可能在未来的研究中进行探讨。
The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique potential for nuclear magnetic resonance (NMR)-based studies. This review summarizes the recent advances in this field, focusing on (i) the strengths of the system, (ii) the bottlenecks that may be faced, and (iii) promising capabilities that may be explored in future studies.