Dynamics of the higher-order structure of chromatin
Dynamics of the higher-order structure of chromatin
复制标题
染色质高级结构的动力学
DOI：
10.1007/s13238-010-0130-y
复制
发表时间：
2010-11-01
期刊：
影响因子：
21.1
通讯作者：
Li, Guohong
中科院分区：
文献类型：
--
作者：
Chen, Ping;Li, Guohong
真核DNA被层次化地包装成染色质，以适应细胞核。染色质结构的动态变化在转录调控和其他涉及DNA的生物过程中起着关键作用，如DNA复制和DNA修复。许多因素，包括组蛋白变体、组蛋白修饰、DNA甲基化和非组蛋白结构蛋白的结合，调节着染色质的结构。尽管染色质的基本重复单位核小体的结构已经很清楚，但关于染色质结构的更高层次的讨论仍然很多。因此，识别高阶染色质纤维的结构细节和动力学对于理解基因活性的组织和调控非常重要。本文就染色质高级结构的动态变化及其与基因转录的关系进行综述。
Eukaryotic DNA is hierarchically packaged into chromatin to fit inside the nucleus. Dynamics of the chromatin structure plays a critical role in transcriptional regulation and other biological processes that involve DNA, such as DNA replication and DNA repair. Many factors, including histone variants, histone modification, DNA methylation and the binding of non-histone architectural proteins regulate the structure of chromatin. Although the structure of nucleosomes, the fundamental repeating unit of chromatin, is clear, there is still much discussion on the higher-order levels of chromatin structure. Identifying the structural details and dynamics of higher-order chromatin fibers is therefore very important for understanding the organization and regulation of gene activities. Here, we review studies on the dynamics of chromatin higherorder structure and its relationship with gene transcription.