Magnetic resonance imaging for area at risk, myocardial infarction, and myocardial salvage.
Magnetic resonance imaging for area at risk, myocardial infarction, and myocardial salvage.
复制标题
DOI：
10.1177/1074248411412378
复制
发表时间：
2011-09
影响因子：
2.6
通讯作者：
Arai AE
中科院分区：
文献类型：
--
作者：
Arai AE
几乎所有发表的心脏保护剂的临床前研究都包括风险面积、梗死面积的测量，因此可以确定心肌挽救作为治疗获益的指标。直到最近，在介入前注射sestamibi的SPECT成像是唯一适合对患者进行类似评估的临床方法。在过去的5年中，大量的论文已经证明MRI可以无创地确定危险区域、梗死面积和心肌挽救。虽然T2加权成像是最常用的方法，但造影前T1加权图像和早期钆增强（EGE）图像也可以确定风险区域的大小。所有这三种MRI方法都基于缺血引起的心肌水肿来检测危险区域。在所有这些方法中，晚期钆增强（LGE）图像为梗死面积提供了一个公认的参考标准。最后，晚期钆增强图像还可以提供基于与急性MI相关的进行性更严重损伤相关的心肌损伤的“波前”的心肌挽救的单一模态测量。基本上，晚期钆增强图像可以提供基于心肌梗死面积的内分泌快照，并且挽救的心肌被估计为梗死周向范围内的存活心肌。因此，本综述的目的是提供一个概述如何MRI可以确定危险区，梗死面积，从而衡量心肌挽救。
Almost all published pre-clinical studies of cardioprotective agents include a measurement of area at risk, infarct size, and thus allow determination of myocardial salvage as an indicator of therapeutic benefit. Until recently, SPECT imaging with injection of sestamibi prior to intervention was the only clinical method suitable for making similar assessments in patients. Over the past 5 years, a large number of papers have documented that MRI can non-invasively determine area at risk, infarct size, and myocardial salvage. While T2 weighted imaging has been the method used most commonly, pre-contrast T1 weighted images, and early gadolinium enhancement (EGE) images can also determine the size of the area at risk. All three of these MRI methods detect the area at risk based on myocardial edema resulting from ischemia. Late gadolinium enhancement (LGE) images provide a well -accepted reference standard for infarct size in all of those methods. Finally, late gadolinium enhancement images can also provide a single modality measure of myocardial salvage based on the “wavefront” of myocardial injury associated with the progressively more severe damage associated with acute MI. Essentially, the late gadolinium enhanced images can provide an endocardial based snap shot of infarct size and salvaged myocardium is estimated as the viable myocardium within the circumferential extent of the infarct. Thus, the purpose of this review is to provide an overview of how MRI can determine area at risk, infarct size, and thus measure myocardial salvage.
登录
查看更多内容
影响因子：
37.8
作者：
Gonzalez, Felix M.;Shiva, Sruti;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
49.6
作者：
Friedrich, Matthias G.
通讯作者：
Friedrich, Matthias G.
DOI：
10.1161/circimaging.109.900761
发表时间：
2010-09
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Berry C;Kellman P;Mancini C;Chen MY;Bandettini WP;Lowrey T;Hsu LY;Aletras AH;Arai AE
通讯作者：
Arai AE
DOI：
10.1161/circinterventions.110.957902
发表时间：
2010-10-01
影响因子：
5.6
作者：
Gotberg, Matthias;Olivecrona, Goran K.;Erlinge, David
通讯作者：
Erlinge, David
影响因子：
20.1
作者：
JENNINGS, RB;SCHAPER, J;REIMER, KA
通讯作者：
REIMER, KA