The functional roles of the circRNA/Wnt axis in cancer.
The functional roles of the circRNA/Wnt axis in cancer.
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DOI：
10.1186/s12943-022-01582-0
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发表时间：
2022-05-05
期刊：
影响因子：
37.3
通讯作者：
Li, Lanjuan
中科院分区：
文献类型：
--
作者：
Xue, Chen;Li, Ganglei;Zheng, Qiuxian;Gu, Xinyu;Bao, Zhengyi;Lu, Juan;Li, Lanjuan
CircRNA是共价闭合的非编码RNA，在从病毒到植物再到哺乳动物的广泛物种中广泛表达。CircRNA在Wnt途径中富集。异常的Wnt通路激活参与各种类型癌症的发展。越来越多的证据表明，circRNA/Wnt轴调节癌症相关基因的表达，从而调节癌症的进展。Wnt通路相关的circRNA表达与许多临床特征明显相关。CircRNA可以通过与Wnt信号通路相互作用来调节细胞的生物学功能。此外，Wnt通路相关的circRNA是用于癌症诊断、预后评估和治疗的有希望的潜在生物标志物。本文就Wnt通路相关circRNA在肿瘤发生发展中的作用及其临床应用的研究进展作一综述。
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.
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影响因子：
12.8
作者：
Caramuta, S.;Lee, L.;Ozata, D. M.;Akcakaya, P.;Georgii-Hemming, P.;Xie, H.;Amini, R-M;Lawrie, C. H.;Enblad, G.;Larsson, C.;Berglund, M.;Lui, W-O
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Lui, W-O
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作者：
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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