Biogenesis of secretory granules.
Biogenesis of secretory granules.
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DOI：
10.1016/1043-4682(92)90021-m
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发表时间：
1992-10-01
期刊：
影响因子：
--
通讯作者：
Stinchcombe, J C
中科院分区：
文献类型：
--
作者：
Tooze, S A;Stinchcombe, J C
内分泌细胞、神经内分泌细胞和外分泌细胞中分泌颗粒的生物发生被认为涉及受调节的分泌蛋白选择性聚集成致密核心结构。然后，致密核心被跨高尔基体网络和芽中的膜包裹，形成未成熟的分泌颗粒。然后，未成熟的分泌颗粒经历成熟过程，产生成熟的分泌颗粒。这里总结了有关聚合、萌芽和成熟过程的最新数据。此外，还回顾了目前关于成熟分泌颗粒的知识，重点是该细胞器膜的生物发生。
The biogenesis of secretory granules in endocrine, neuroendocrine, and exocrine cells is thought to involve a selective aggregation of the regulated secretory proteins into a dense-cored structure. The dense-core is then enveloped by membrane in the trans-Golgi network and buds, forming an immature secretory granule. The immature secretory granule then undergoes a maturation process which gives rise to the mature secretory granule. The recent data on the processes of aggregation, budding and maturation are summarized here. In addition, the current knowledge about the mature secretory granule is reviewed with emphasis on the biogenesis of the membrane of this organelle.