5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder
5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder
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DOI：
10.1097/yic.0b013e328338bcf4
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发表时间：
2010-07
影响因子：
2.6
通讯作者：
Magali Noro;I. Antonijevic;C. Forray;S. Kasper;N. Kocabas;Y. Lecrubier;S. Linotte;J. Mendlewicz;S. Montgomery;Lenore Snyder;D. Souery;P. Verbanck;J. Zohar;I. Massat
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文献类型：
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作者：
Magali Noro;I. Antonijevic;C. Forray;S. Kasper;N. Kocabas;Y. Lecrubier;S. Linotte;J. Mendlewicz;S. Montgomery;Lenore Snyder;D. Souery;P. Verbanck;J. Zohar;I. Massat
5 HT 2A（5 HTR 2A）和5 HT 1A受体（5 HTR 1A）基因是重度抑郁症的可能候选基因。采用《精神疾病诊断与统计手册》第四版对206例重性抑郁症患者进行了5-HTR 2A基因rs7997012和5-HTR 1A基因-1019C/G单核苷酸多态性分析。回顾性分析患者对抗抑郁治疗的临床反应。我们发现耐药和非耐药患者之间rs7997012等位基因频率存在显著差异。然而，在Bonferroni校正之后，我们没有发现这种单核苷酸多态性与治疗抗性表型之间的任何关联。尽管如此，由于我们的分析能力有限，我们无法得出结论，这些结果反映了缺乏关联。需要更多的研究来证实或反驳我们的结果。
The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the –1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.