Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms
Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms
复制标题
DOI：
10.1364/ao.45.001062
复制
发表时间：
2006-02-10
期刊：
影响因子：
1.9
通讯作者：
Ramanujam, N
中科院分区：
文献类型：
--
作者：
Palmer, GM;Ramanujam, N
提出了一种灵活、快速的基于蒙特卡罗的漫反射模型，用于提取混浊介质（如人体组织）的吸收和散射特性。该方法适用于各种光学特性，并且很容易适应现有的探头几何形状，前提是进行单个体模校准测量。为了加快前向模拟的速度，采用了压缩蒙特卡罗方法。该模型通过使用两套液体组织模型进行验证，所述两套液体组织模型包含作为吸收体的黑曲霉素或血红蛋白和作为散射体的聚苯乙烯球。该模型具有宽的吸收范围（0-20 cm（-1））和降低的散射系数（7-33 cm（-1））。用米氏理论和分光光度计测定了该模型的吸收系数和约化散射系数。在350-850 nm的波长范围内测量该模型的漫反射光谱。结果发现，光学性质可以提取从实验测得的漫反射光谱的平均误差为3%或更少的含血红蛋白的幻影和12%或更少的幻影含有黑曲霉素。(c)2006年美国光学学会。
A flexible and fast Monte Carlo-based model of diffuse reflectance has been developed for the extraction of the absorption and scattering properties of turbid media, such as human tissues. This method is valid for a wide range of optical properties and is easily adaptable to existing probe geometries, provided a single phantom calibration measurement is made. A condensed Monte Carlo method was used to speed up the for-ward simulations. This model was validated by use of two sets of liquid-tissue phantoms containing Nigrosin or hemoglobin as absorbers and polystyrene spheres as scatterers. The phantoms had a wide range of absorption (0-20 cm(-1)) and reduced scattering coefficients (7-33 cm(-1)). Mie theory and a spectrophotometer were used to determine the absorption and reduced scattering coefficients of the phantoms. The diffuse reflectance spectra of the phantoms were measured over a wavelength range of 350-850 nm. It was found that optical properties could be extracted from the experimentally measured diffuse reflectance spectra with an average error of 3% or less for phantoms containing hemoglobin and 12% or less for phantoms containing Nigrosin. (c) 2006 Optical Society of America.