Redox control of skeletal muscle atrophy.
Redox control of skeletal muscle atrophy.
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DOI：
10.1016/j.freeradbiomed.2016.02.021
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发表时间：
2016-09
影响因子：
7.4
通讯作者：
Smuder, Ashley J.
中科院分区：
文献类型：
--
作者：
Powers, Scott K.;Morton, Aaron B.;Ahn, Bumsoo;Smuder, Ashley J.
关键词：
骨骼肌构成了体内最大的器官系统，在身体运动、呼吸和葡萄糖稳态中发挥着重要作用。骨骼肌也是重要的内分泌器官，有助于许多身体器官的健康。因此，保持健康的骨骼肌对于支持身体的整体健康非常重要。长时间的肌肉不活动（例如卧床休息或肢体固定）或慢性炎症性疾病（例如癌症、肾衰竭等）会导致骨骼肌萎缩。肌肉质量的过度损失与多种疾病的不良预后有关，并且严重的肌肉无力会损害生活质量。因炎症性疾病或长期不活动而发生的骨骼肌萎缩通常与氧化应激和亚硝化应激有关。在本报告中，我们批判性地回顾了为氧化剂与肌肉萎缩之间的因果关系提供支持的实验证据。更具体地说，这篇综述将讨论正在萎缩的骨骼肌中氧化剂产生的来源，并详细讨论活性氧和活性氮如何调节调节蛋白质合成和蛋白质分解的信号通路。
Skeletal muscles comprise the largest organ system in the body and play an essential role in body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important endocrine organ that contributes to the health of numerous body organs. Therefore, maintaining healthy skeletal muscles is important to support overall health of the body. Prolonged periods of muscle inactivity (e.g., bed rest or limb immobilization) or chronic inflammatory diseases (i.e., cancer, kidney failure, etc.) result in skeletal muscle atrophy. An excessive loss of muscle mass is associated with a poor prognosis in several diseases and significant muscle weakness impairs the quality of life. The skeletal muscle atrophy that occurs in response to inflammatory diseases or prolonged inactivity is often associated with both oxidative and nitrosative stress. In this report, we critically review the experimental evidence that provides support for a causative link between oxidants and muscle atrophy. More specifically, this review will debate the sources of oxidant production in skeletal muscle undergoing atrophy as well as provide a detailed discussion on how reactive oxygen species and reactive nitrogen species modulate the signaling pathways that regulate both protein synthesis and protein breakdown.
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DOI：
10.1006/bmme.1997.2598
发表时间：
1997-08-01
期刊：
BIOCHEMICAL AND MOLECULAR MEDICINE
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
19
作者：
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通讯作者：
Klionsky, Daniel J.
影响因子：
7.4
作者：
Kavazis, Andreas N.;Talbert, Erin E.;Smuder, Ashley J.;Hudson, Matthew B.;Nelson, W. Bradley;Powers, Scott K.
通讯作者：
Powers, Scott K.
DOI：
10.1016/s0006-291x(03)00809-x
发表时间：
2003-06-06
影响因子：
3.1
作者：
Grune, T;Merker, K;Davies, KJA
通讯作者：
Davies, KJA