Glioblastoma simultaneously present with meningioma - Report of three cases
Glioblastoma simultaneously present with meningioma - Report of three cases
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DOI：
10.1055/s-2007-981673
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发表时间：
2007-08-01
影响因子：
--
通讯作者：
Kuchelmeister, K. W.
中科院分区：
文献类型：
--
作者：
Nestler, U.;Schmidinger, A.;Kuchelmeister, K. W.
背景资料：大多数原发性颅内肿瘤为孤立性病变;一个肿瘤的多个位置，两个不同肿瘤的发生甚至碰撞肿瘤仅在少数患者中有描述。从统计学的角度来看，在不到100例胶质母细胞瘤病例中，脑膜瘤同时存在于大脑中。我们报告三例这种巧合，并显示CGH和染色体分析的结果，在两个病人中，肿瘤出现在非常密切的空间相关性，以对方Patients：我们描述了三个病例的历史，同时发生脑膜瘤和胶质母细胞瘤所示的MRI入院。神经外科手术切除肿块病变后，从两个病人的标本培养在细胞培养和细胞进行了检查染色体畸变的常规核型分析以及比较基因组杂交（CGH）。结果：检查揭示了一个脑膜瘤和两个胶质母细胞瘤的特征遗传畸变。在一个病人中，它是可能的比较脑膜瘤和胶质母细胞瘤的数据，在这种情况下，我们没有发现一个共同的遗传畸变在肿瘤细胞具有不同的组织学。结论：肿瘤细胞的基因检测应常规进行时，不同的组织学类型的脑肿瘤是存在于一个密切的空间关系。我们赞成两种肿瘤同时发生的统计学巧合假设，而不是产生两种肿瘤实体的共同途径。
Background: Most primary intracranial tumors occur as solitary lesions; multiple locations of one tumor, the occurrence of two different tumors or even collision tumors have been described only in a few patients. From a statistical point of view, in less than 100 glioblastoma cases will a meningioma be simultaneously present in the brain. We report three cases with this coincidence and display the results of CGH and chromosome analysis in two patients, in whom the tumors arose in very close spatial correlation to each other.Patients: We describe three case histories with simultaneous occurrence of meningioma and glioblastoma as shown by MRI on admission. After neurosurgical removal of mass lesions, specimens from two patients were cultivated in cell culture and the cells were examined for chromosomal aberrations by conventional karyotyping as well as comparative genomic hybridization (CGH).Results: Examinations disclosed characteristic genetic aberrations for one meningioma and two glioblastomas. In one patient it was possible to compare the data for the meningioma and the glioblastoma; in this case we did not find a common genetic aberration in tumor cells with a different histology.Conclusion: Genetic testing of tumor cells should be performed routinely when different histological types of brain tumors are present in a close spatial relationship. We favor the hypothesis of statistical coincidence for the simultaneous occurrence of the two tumors rather than a common pathway giving rise to two tumor entities.