eXclusion: Toward Integrating the X Chromosome in Genome-wide Association Analyses
eXclusion: Toward Integrating the X Chromosome in Genome-wide Association Analyses
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DOI：
10.1016/j.ajhg.2013.03.017
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发表时间：
2013-05-02
影响因子：
9.8
通讯作者：
Manolio, Teri A.
中科院分区：
文献类型：
--
作者：
Wise, Anastasia L.;Gyi, Lin;Manolio, Teri A.
在全基因组关联研究（GWAS）中，X染色体落后于常染色体。事实上，尽管在所有当前的GWAS微阵列平台上进行了测定，但X染色体通常被排除在GWAS分析之外。这就提出了一个问题：为什么在X染色体上报告的命中如此之少？这篇评论旨在通过对国家人类基因组研究所公布的全基因组关联研究目录（NHGRI GWAS目录）中当前X染色体结果的回顾来研究这个问题。它还将调查从GWAS中排除X染色体的常见原因，并审查目前可用于X染色体分析的工具。最后将提出在未来研究中纳入X染色体分析的建议。
The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Studies (NHGRI GWAS Catalog). It will also investigate commonly cited reasons for exclusion of the X chromosome from GWAS and review the tools currently available for X chromosome analysis. It will conclude with recommendations for incorporating X chromosome analyses in future studies.